Locus Coeruleus and Dopamine-Dependent Memory Consolidation
Joint Authors
Yamasaki, Miwako
Takeuchi, Tomonori
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-16
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Most everyday memories including many episodic-like memories that we may form automatically in the hippocampus (HPC) are forgotten, while some of them are retained for a long time by a memory stabilization process, called initial memory consolidation.
Specifically, the retention of everyday memory is enhanced, in humans and animals, when something novel happens shortly before or after the time of encoding.
Converging evidence has indicated that dopamine (DA) signaling via D1/D5 receptors in HPC is required for persistence of synaptic plasticity and memory, thereby playing an important role in the novelty-associated memory enhancement.
In this review paper, we aim to provide an overview of the key findings related to D1/D5 receptor-dependent persistence of synaptic plasticity and memory in HPC, especially focusing on the emerging evidence for a role of the locus coeruleus (LC) in DA-dependent memory consolidation.
We then refer to candidate brain areas and circuits that might be responsible for detection and transmission of the environmental novelty signal and molecular and anatomical evidence for the LC-DA system.
We also discuss molecular mechanisms that might mediate the environmental novelty-associated memory enhancement, including plasticity-related proteins that are involved in initial memory consolidation processes in HPC.
American Psychological Association (APA)
Yamasaki, Miwako& Takeuchi, Tomonori. 2017. Locus Coeruleus and Dopamine-Dependent Memory Consolidation. Neural Plasticity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1193268
Modern Language Association (MLA)
Yamasaki, Miwako& Takeuchi, Tomonori. Locus Coeruleus and Dopamine-Dependent Memory Consolidation. Neural Plasticity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1193268
American Medical Association (AMA)
Yamasaki, Miwako& Takeuchi, Tomonori. Locus Coeruleus and Dopamine-Dependent Memory Consolidation. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1193268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193268