The Role of Flavonoids in Inhibiting Th17 Responses in Inflammatory Arthritis
Joint Authors
Sakkas, Lazaros I.
Bogdanos, Dimitrios P.
Kelepouri, Dimitra
Mavropoulos, Athanasios
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Flavonoids have been considered powerful anti-inflammatory agents, and their exact immunomodulatory action as therapeutic agents in autoimmune diseases has started to emerge.
Their role in the manipulation of immunoregulation is less understood.
Several studies attempted to investigate the role of various flavonoids mainly in experimental models of autoimmune diseases, especially in the context of their potential effect on the increase of regulatory T cells (Tregs) and their ability to stimulate an overexpression of anti-inflammatory cytokines, in particular that of IL-10.
The emergence of IL-17, a cytokine largely produced by Th17 cells, as a powerful proinflammatory stimulus which attenuates the induction of Tregs has prompted a series of studies investigating the role of flavonoids on Th17 cells in experimental models as well as human autoimmune diseases.
This review thoroughly discusses accumulated data on the role of flavonoids on Th17 in rheumatoid arthritis and experimental autoimmune arthritis.
American Psychological Association (APA)
Kelepouri, Dimitra& Mavropoulos, Athanasios& Bogdanos, Dimitrios P.& Sakkas, Lazaros I.. 2018. The Role of Flavonoids in Inhibiting Th17 Responses in Inflammatory Arthritis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1193270
Modern Language Association (MLA)
Kelepouri, Dimitra…[et al.]. The Role of Flavonoids in Inhibiting Th17 Responses in Inflammatory Arthritis. Journal of Immunology Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1193270
American Medical Association (AMA)
Kelepouri, Dimitra& Mavropoulos, Athanasios& Bogdanos, Dimitrios P.& Sakkas, Lazaros I.. The Role of Flavonoids in Inhibiting Th17 Responses in Inflammatory Arthritis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1193270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193270