The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity
Joint Authors
Madalena, Kathryn M.
Lerch, Jessica K.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Stress, injury, and disease trigger glucocorticoid (GC) elevation.
Elevated GCs bind to the ubiquitously expressed glucocorticoid receptor (GR).
While GRs are in every cell in the nervous system, the expression level varies, suggesting that diverse cell types react differently to GR activation.
Stress/GCs induce structural plasticity in neurons, Schwann cells, microglia, oligodendrocytes, and astrocytes as well as affect neurotransmission by changing the release and reuptake of glutamate.
While general nervous system plasticity is essential for adaptation and learning and memory, stress-induced plasticity is often maladaptive and contributes to neuropsychiatric disorders and neuropathic pain.
In this brief review, we describe the evidence that stress/GCs activate GR to promote cell type-specific changes in cellular plasticity throughout the nervous system.
American Psychological Association (APA)
Madalena, Kathryn M.& Lerch, Jessica K.. 2017. The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity. Neural Plasticity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1193274
Modern Language Association (MLA)
Madalena, Kathryn M.& Lerch, Jessica K.. The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity. Neural Plasticity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1193274
American Medical Association (AMA)
Madalena, Kathryn M.& Lerch, Jessica K.. The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1193274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193274