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The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis
Joint Authors
Ammirati, Enrico
Moroni, Francesco
Magnoni, Marco
Camici, Paolo G.
Norata, Giuseppe Danilo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Atherosclerosis is one of the leading causes of death and disability worldwide.
It is a complex disease characterized by lipid accumulation within the arterial wall, inflammation, local neoangiogenesis, and apoptosis.
Innate immune effectors, in particular monocytes and macrophages, play a pivotal role in atherosclerosis initiation and progression.
Although most of available evidence on the role of monocytes and macrophages in atherosclerosis is derived from animal studies, a growing body of evidence elucidating the role of these mononuclear cell subtypes in human atherosclerosis is currently accumulating.
A novel pathogenic role of monocytes and macrophages in terms of atherosclerosis initiation and progression, in particular concerning the role of these cell subsets in neovascularization, has been discovered.
The aim of the present article is to review currently available evidence on the role of monocytes and macrophages in human atherosclerosis and in relation to plaque characteristics, such as plaque neoangiogenesis, and patients’ prognosis and their potential role as biomarkers.
American Psychological Association (APA)
Moroni, Francesco& Ammirati, Enrico& Norata, Giuseppe Danilo& Magnoni, Marco& Camici, Paolo G.. 2019. The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1193279
Modern Language Association (MLA)
Moroni, Francesco…[et al.]. The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis. Mediators of Inflammation No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1193279
American Medical Association (AMA)
Moroni, Francesco& Ammirati, Enrico& Norata, Giuseppe Danilo& Magnoni, Marco& Camici, Paolo G.. The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1193279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193279