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The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood
Joint Authors
Alassiri, Saeed
Tervahartiala, Taina
Savonius, Okko
Roine, Irmeli
Helve, Otto
Fernández, Josefina
Peltola, Heikki
Pelkonen, Tuula
Sorsa, Timo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) contribute to the inflammatory cascade in the cerebrospinal fluid (CSF) during bacterial meningitis.
We determined levels of MPO, MMP-8, MMP-9, and tissue inhibitor of metalloproteinase- (TIMP-) 1 in the CSF of children with bacterial meningitis and investigated how these inflammatory mediators relate to each other and to the disease outcomes.
Methods.
Clinical data and the diagnostic CSF samples from 245 children (median age eight months) with bacterial meningitis were obtained from a clinical trial in Latin America in 1996–2003.
MMP-9 levels in the CSF were assessed by zymography, while MMP-8, MPO, and TIMP-1 concentrations were determined with immunofluorometric and enzyme-linked immunosorbent assays.
Results.
MPO correlated positively with MMP-8 (rho 0.496, P<0.001) and MMP-9 (rho 0.153, P=0.02) but negatively with TIMP-1 (rho -0.361, P<0.001).
MMP-8 emerged as the best predictor of disease outcomes: a CSF MMP-8 concentration above the median increased the odds of death 4.9-fold (95% confidence interval 1.8–12.9).
Conclusions.
CSF MMP-8 presented as an attractive prognostic marker in children with bacterial meningitis.
American Psychological Association (APA)
Savonius, Okko& Roine, Irmeli& Alassiri, Saeed& Tervahartiala, Taina& Helve, Otto& Fernández, Josefina…[et al.]. 2019. The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1193280
Modern Language Association (MLA)
Savonius, Okko…[et al.]. The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood. Mediators of Inflammation No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1193280
American Medical Association (AMA)
Savonius, Okko& Roine, Irmeli& Alassiri, Saeed& Tervahartiala, Taina& Helve, Otto& Fernández, Josefina…[et al.]. The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1193280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193280