Neural Plasticity Associated with Hippocampal PKA-CREB and NMDA Signaling Is Involved in the Antidepressant Effect of Repeated Low Dose of Yueju Pill on Chronic Mouse Model of Learned Helplessness
Joint Authors
Chen, Gang
Zou, Zhilu
Chen, Yin
Shen, Qinqin
Guo, Xiaoyan
Zhang, Yuxuan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Yueju pill is a traditional Chinese medicine formulated to treat syndromes of mood disorders.
Here, we investigated the therapeutic effect of repeated low dose of Yueju in the animal model mimicking clinical long-term depression condition and the role of neural plasticity associated with PKA- (protein kinase A-) CREB (cAMP response element binding protein) and NMDA (N-methyl-D-aspartate) signaling.
We showed that a single low dose of Yueju demonstrated antidepressant effects in tests of tail suspension, forced swim, and novelty-suppressed feeding.
A chronic learned helplessness (LH) protocol resulted in a long-term depressive-like condition.
Repeated administration of Yueju following chronic LH remarkably alleviated all of depressive-like symptoms measured, whereas conventional antidepressant fluoxetine only showed a minor improvement.
In the hippocampus, Yueju and fluoxetine both normalized brain-derived neurotrophic factor (BDNF) and PKA level.
Only Yueju, not fluoxetine, rescued the deficits in CREB signaling.
The chronic LH upregulated the expression of NMDA receptor subunits NR1, NR2A, and NR2B, which were all attenuated by Yueju.
Furthermore, intracerebraventricular administration of NMDA blunted the antidepressant effect of Yueju.
These findings supported the antidepressant efficacy of repeated routine low dose of Yueju in a long-term depression model and the critical role of CREB and NMDA signaling.
American Psychological Association (APA)
Zou, Zhilu& Chen, Yin& Shen, Qinqin& Guo, Xiaoyan& Zhang, Yuxuan& Chen, Gang. 2017. Neural Plasticity Associated with Hippocampal PKA-CREB and NMDA Signaling Is Involved in the Antidepressant Effect of Repeated Low Dose of Yueju Pill on Chronic Mouse Model of Learned Helplessness. Neural Plasticity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193329
Modern Language Association (MLA)
Zou, Zhilu…[et al.]. Neural Plasticity Associated with Hippocampal PKA-CREB and NMDA Signaling Is Involved in the Antidepressant Effect of Repeated Low Dose of Yueju Pill on Chronic Mouse Model of Learned Helplessness. Neural Plasticity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1193329
American Medical Association (AMA)
Zou, Zhilu& Chen, Yin& Shen, Qinqin& Guo, Xiaoyan& Zhang, Yuxuan& Chen, Gang. Neural Plasticity Associated with Hippocampal PKA-CREB and NMDA Signaling Is Involved in the Antidepressant Effect of Repeated Low Dose of Yueju Pill on Chronic Mouse Model of Learned Helplessness. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193329