Effects of Propofol Treatment in Neural Progenitors Derived from Human-Induced Pluripotent Stem Cells
Joint Authors
Long, Bo
Li, Shenglan
Xue, Haipeng
Sun, Li
Kim, Dong H.
Liu, Ying
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Propofol is an intravenous anesthetic that has been widely used in clinics.
Besides its anesthetic effects, propofol has also been reported to influence the regulation of the autonomic system.
Controversies exist with regard to whether propofol exposure is safe for pregnant women and young children.
In this work, human-induced pluripotent stem cell- (hiPSC-) derived neural progenitor cells (NPCs) were treated with propofol at 20, 50, 100, or 300 μM for 6 h or 24 h, and acute and subacute cell injury, cell proliferation, and apoptosis were evaluated.
Comparison of genome-wide gene expression profiles was performed for treated and control iPSC-NPCs.
Propofol treatment for 6 h at the clinically relevant concentration (20 or 50 μM) did not affect cell viability, apoptosis, or proliferation, while propofol at higher concentration (100 or 300 μM) decreased NPC viability and induced apoptosis.
In addition, 20 μM propofol treatment for 6 h did not alter global gene expression.
In summary, propofol treatment at commonly practiced clinical doses for 6 h did not have adverse effects on hiPSC-derived NPCs.
In contrast, longer exposure and/or higher concentration could decrease NPC viability and induce apoptosis.
American Psychological Association (APA)
Long, Bo& Li, Shenglan& Xue, Haipeng& Sun, Li& Kim, Dong H.& Liu, Ying. 2017. Effects of Propofol Treatment in Neural Progenitors Derived from Human-Induced Pluripotent Stem Cells. Neural Plasticity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193340
Modern Language Association (MLA)
Long, Bo…[et al.]. Effects of Propofol Treatment in Neural Progenitors Derived from Human-Induced Pluripotent Stem Cells. Neural Plasticity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193340
American Medical Association (AMA)
Long, Bo& Li, Shenglan& Xue, Haipeng& Sun, Li& Kim, Dong H.& Liu, Ying. Effects of Propofol Treatment in Neural Progenitors Derived from Human-Induced Pluripotent Stem Cells. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193340