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NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway
Joint Authors
Sun, Jing
Li, Hui
Xu, Zhi-Qing David
Wang, Wenjiao
Xu, Tao
Chen, Xinyue
Dong, Kemeng
Du, Chunkai
Shi, Cuige
Li, Xiaoxiao
Yang, Yutao
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Accumulated evidences show that neuroinflammation play a pivotal role in the pathogenesis of depression.
Neuropeptide Y (NPY) and its receptors have been demonstrated to have anti-inflammative as well as antidepressant effects.
In the present study, the ability of NPY to modulate depressive-like behaviors induced by lipopolysaccharides (LPS) in rats and the receptors and signaling mechanisms involved were investigated.
Continuous injection LPS (i.p) for 4 days led to development of depressive-like behaviors in rats, accompanied with M1-type microglia activation and increased levels of IL-1β as well as decreased levels of NPY and Y2R expression in the mPFC selectively.
Local injection of NPY into the medial prefrontal cortex (mPFC) ameliorated the depression-like behaviors and suppressed the NLRP3 inflammasome signaling pathway.
Y2R agonist PYY (3-36) mimicked and Y2R antagonist BIIE0246 abolished the NPY effects in the mPFC.
All these results suggest that NPY and Y2R in the mPFC are involved in the pathophysiology of depression and NPY plays an antidepressant role in the mPFC mainly via Y2R, which suppresses the NLRP3 signaling pathway, in LPS-induced depression model rats.
American Psychological Association (APA)
Wang, Wenjiao& Xu, Tao& Chen, Xinyue& Dong, Kemeng& Du, Chunkai& Sun, Jing…[et al.]. 2019. NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193341
Modern Language Association (MLA)
Wang, Wenjiao…[et al.]. NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway. Mediators of Inflammation No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1193341
American Medical Association (AMA)
Wang, Wenjiao& Xu, Tao& Chen, Xinyue& Dong, Kemeng& Du, Chunkai& Sun, Jing…[et al.]. NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193341