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Analysis of Sodium Chloride Intake and TregTh17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus
Joint Authors
Layseca-Espinosa, Esther
Rosenstein, Y.
Vitales-Noyola, Marlen
Abud-Mendoza, Carlos
Niño-Moreno, Perla
Monsiváis-Urenda, Adriana
González-Amaro, Roberto
Baranda, Lourdes
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We assessed different immune parameters in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) with low (LSI) and high (HSI) sodium intake.
Thirty-eight patients with RA, thirty-seven with SLE, and twenty-eight healthy subjects were studied and classified as LSI or HSI.
Levels and suppressive function of CD4+CD25+Foxp3+ and CD4+CD69+Foxp3− Treg cells were determined by flow cytometry in blood samples.
Levels and in vitro differentiation of Th17 cells were also assessed.
Similar levels of CD4+CD25+Foxp3+ and CD4+CD69+Foxp3− Treg cells were observed in LSI and HSI patients or controls.
However, a positive correlation was detected between sodium intake and levels of CD4+CD25+Foxp3+ Treg cells in SLE and a negative association between CD4+CD69+Foxp3− Treg cells and sodium intake in RA.
No other significant associations were detected, including disease activity and sodium intake.
Moreover, the suppressor activity of CD4+CD25+Foxp3+ and CD4+CD69+Foxp3− Treg cells was similar in LSI and HSI patients or controls.
The levels and in vitro differentiation of Th17 cells were also similar in LSI and HSI individuals.
Our results suggest that, in the population studied (Mexican mestizo), the level of sodium intake is not apparently associated with different relevant immune parameters in healthy subjects or patients with SLE or RA.
American Psychological Association (APA)
Vitales-Noyola, Marlen& Layseca-Espinosa, Esther& Baranda, Lourdes& Abud-Mendoza, Carlos& Niño-Moreno, Perla& Monsiváis-Urenda, Adriana…[et al.]. 2018. Analysis of Sodium Chloride Intake and TregTh17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1193346
Modern Language Association (MLA)
Vitales-Noyola, Marlen…[et al.]. Analysis of Sodium Chloride Intake and TregTh17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus. Journal of Immunology Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1193346
American Medical Association (AMA)
Vitales-Noyola, Marlen& Layseca-Espinosa, Esther& Baranda, Lourdes& Abud-Mendoza, Carlos& Niño-Moreno, Perla& Monsiváis-Urenda, Adriana…[et al.]. Analysis of Sodium Chloride Intake and TregTh17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1193346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193346