Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors

Abstract EN

Communication between neuronal and glial cells is important for neural plasticity.

P2X receptors are ATP-gated cation channels widely expressed in the brain where they mediate action of extracellular ATP released by neurons and/or glia.

Recent data show that postsynaptic P2X receptors underlie slow neuromodulatory actions rather than fast synaptic transmission at brain synapses.

Here, we review these findings with a particular focus on the release of ATP by astrocytes and the diversity of postsynaptic P2X-mediated modulation of synaptic strength and plasticity in the CNS.