Association of Genetic Variants of RANK, RANKL, and OPG with Ankylosing Spondylitis Clinical Features in Taiwanese
Joint Authors
Chen, Ji-Yih
Wang, Chin-Man
Tsai, Shu-Chun
Lin, Jing-Chi
Wu, Yeong-Jian Jan
Wu, Jianming
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Ankylosing spondylitis (AS) is a chronic inflammatory disease that leads to spinal ankylosis.
The receptor activator of the nuclear factor-kappa (RANK), RANK ligand, and osteoprotegerin (OPG) (RANK/RANKL/OPG) pathway plays critical roles in bone metabolism and the immune system.
The current study was aimed at investigating whether six single-nucleotide polymorphisms (SNPs) within the RANK, RANKL, and OPG genes essential for bone homeostasis are associated with AS.
Genotype distributions, allele and haplotype frequencies, were compared between 1120 AS patients and 1435 healthy controls and among AS patients with stratification by syndesmophyte formation, onset age, and HLA-B27 positivity.
We found that RANKL SNPs were associated with AS syndesmophyte formation.
Notably, the RANKL SNP haplotype rs7984870C/rs9533155G/rs9525641C was negatively associated with AS susceptibility and appeared to protect against syndesmophyte formation in AS.
Functionally, RANKL promoter SNPs (rs9525641 C/T and rs9533155 G/C) affected DNA-protein complex formation and promoter activity in promoter reporter analyses.
The OPG SNP haplotype rs2073618G/rs3102735T was significantly associated with HLA-B27 negativity in AS patients.
Furthermore, AS patients with syndesmophyte formation had significantly lower levels of soluble RANKL levels than those without syndesmophyte formation.
Our data suggested a role for RANKL in AS susceptibility and severity.
American Psychological Association (APA)
Wang, Chin-Man& Tsai, Shu-Chun& Lin, Jing-Chi& Wu, Yeong-Jian Jan& Wu, Jianming& Chen, Ji-Yih. 2019. Association of Genetic Variants of RANK, RANKL, and OPG with Ankylosing Spondylitis Clinical Features in Taiwanese. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1193373
Modern Language Association (MLA)
Wang, Chin-Man…[et al.]. Association of Genetic Variants of RANK, RANKL, and OPG with Ankylosing Spondylitis Clinical Features in Taiwanese. Mediators of Inflammation No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1193373
American Medical Association (AMA)
Wang, Chin-Man& Tsai, Shu-Chun& Lin, Jing-Chi& Wu, Yeong-Jian Jan& Wu, Jianming& Chen, Ji-Yih. Association of Genetic Variants of RANK, RANKL, and OPG with Ankylosing Spondylitis Clinical Features in Taiwanese. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1193373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193373