Tissue Inhibitor of Metalloproteinase-2 Polymorphisms and Risk for HIV-Associated Neurocognitive Disorder
Joint Authors
Singh, HariOm
Samani, Dharmesh
Jadhav, Sushma
Nain, Sumitra
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The imbalance between MMPs and TIMPs is associated with the HIV dissemination tissue damage pathology neurodegenerative disorders, including HAND.
Genetic variations in the TIMP gene may modulate the neurocognitive disorder in HIV patients.
Hence, we evaluated the genetic variants of TIMP-2 (-418G/C, 303G/A) gene with the risk of HAND.
Genotyping of TIMP-2 polymorphism was performed in 50 patients with HAND, 100 no HAND, and 154 healthy controls by PCR-RFLP.
TIMP-2 -418GC and 303AA genotypes represented a predominant risk for HAND severity (OR=1.55, P=0.30; OR=4.58, P=0.24).
The variant -418CC genotype, -418A allele, had exhibited a significant risk for the acquisition of HAND (OR=12.55, P=0.026; OR=2.66, P=0.004).
TIMP-2 303GA, 303AA genotype, and 303A allele evinced a higher risk for HAND severity (OR=1.82, P=0.14; OR=1.70, P=0.63; and OR=1.68, P=0.12).
In HIV patients, TIMP-2 -418CC genotype and -418C allele significantly occurred in comparison to healthy controls (OR=10.10, P=0.006; OR=2.02, P=0.009).
In the intermediate and early HIV disease stage, TIMP-2 -418CC genotype was significantly increased compared with healthy controls (11.1% vs.
1.3%, OR=14.63, P=0.01; 16.9% vs.
1.3%, OR=14.51, P=0.002).
In patients with HAND among tobacco and alcohol users, TIMP-2 -418CC genotype displayed a risk for HAND severity (OR=3.96, P=0.26; OR=4.83, P=0.19).
On multivariate logistic regression, TIMP-2 303AA genotype, advanced stage, and gender had a risk for HAND severity (OR=28.98, P=0.02; OR=2.35, P=0.070; and OR=2.36, P=0.04).
In conclusion, TIMP-2 -418G/C polymorphism independently, along with alcohol and tobacco, may have an impact on the acquisition of HAND and its severity.
TIMP-2 303G/A polymorphism bare a risk for HAND severity.
American Psychological Association (APA)
Singh, HariOm& Jadhav, Sushma& Samani, Dharmesh& Nain, Sumitra. 2019. Tissue Inhibitor of Metalloproteinase-2 Polymorphisms and Risk for HIV-Associated Neurocognitive Disorder. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1193406
Modern Language Association (MLA)
Singh, HariOm…[et al.]. Tissue Inhibitor of Metalloproteinase-2 Polymorphisms and Risk for HIV-Associated Neurocognitive Disorder. Mediators of Inflammation No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1193406
American Medical Association (AMA)
Singh, HariOm& Jadhav, Sushma& Samani, Dharmesh& Nain, Sumitra. Tissue Inhibitor of Metalloproteinase-2 Polymorphisms and Risk for HIV-Associated Neurocognitive Disorder. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1193406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193406