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Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers
Joint Authors
Taskiran, Dilek
Erbaş, Oytun
Aktuğ, Hüseyin
Solmaz, Volkan
Köse Özlece, Hatice
Eroglu, Hüseyin Avni
Source
Neurology Research International
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar accumulation of α-synuclein in streptozotocin- (STZ-) induced diabetes model in rats.
Methods.
Twelve rats were included in the study.
Diabetes (n=6) was induced with a single intraperitoneal injection of streptozotocin (STZ, 60 mg/kg).
Diabetes was verified after 48 h by measuring blood glucose levels.
Six rats served as controls.
Following 8 weeks, rats were sacrificed for biochemical and immunohistochemical evaluation.
Results.
Plasma MDA levels were significantly higher in diabetic rats when compared with the control rats (p<0.01), while plasma GSH levels were lower in the diabetic group than in the control group (p<0.01).
Also, plasma pentraxin-3 levels were statistically higher in diabetic rats than in the control rats (p<0.01).
The analysis of cerebellar α-synuclein immunohistochemistry showed a significant increase in α-synuclein immunoexpression in the diabetic group compared to the control group (p<0.01).
Conclusion.
Due to increased inflammation and oxidative stress in the chronic period of hyperglycemia linked to diabetes, there may be α-synuclein accumulation in the cerebellum and the plasma PTX3 levels may be assessed as an important biomarker of this situation.
American Psychological Association (APA)
Solmaz, Volkan& Köse Özlece, Hatice& Eroglu, Hüseyin Avni& Aktuğ, Hüseyin& Erbaş, Oytun& Taskiran, Dilek. 2017. Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers. Neurology Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1193414
Modern Language Association (MLA)
Solmaz, Volkan…[et al.]. Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers. Neurology Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1193414
American Medical Association (AMA)
Solmaz, Volkan& Köse Özlece, Hatice& Eroglu, Hüseyin Avni& Aktuğ, Hüseyin& Erbaş, Oytun& Taskiran, Dilek. Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers. Neurology Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1193414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193414