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Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice
Joint Authors
Dong, Hongquan
Wang, Yiwei
Zhou, Qin
Ni, Pengfei
Sun, Menghan
Qian, Yanning
Sun, Jie
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Postoperative cognitive dysfunction (POCD) is defined as new cognitive impairment (memory impairment and impaired performance) after surgery, especially in aged patients.
Sleep disturbance is a common phenomenon before surgery that has been increasingly thought to affect patient recovery.
However, little is known about the functional impact of preoperative sleep disturbance on POCD.
Here, we showed that tibial fracture surgery induced cognitive deficit and production of proinflammatory cytokines interleukin-6 (IL-6) and IL-1β, along with microglia and astrocyte activation, neuronal damage, and blood-brain barrier (BBB) disruption.
Preoperative sleep disturbance enhanced the surgery-induced neuroinflammation, neuronal damage, BBB disruption, and memory impairment 24 h after surgery.
Taken together, these results demonstrated that preoperative sleep disturbance aggravated postoperative cognitive function in aged mice and the mechanism may be related to central nervous system (CNS) inflammation and neuronal damage.
American Psychological Association (APA)
Ni, Pengfei& Dong, Hongquan& Zhou, Qin& Wang, Yiwei& Sun, Menghan& Qian, Yanning…[et al.]. 2019. Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193418
Modern Language Association (MLA)
Ni, Pengfei…[et al.]. Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice. Mediators of Inflammation No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1193418
American Medical Association (AMA)
Ni, Pengfei& Dong, Hongquan& Zhou, Qin& Wang, Yiwei& Sun, Menghan& Qian, Yanning…[et al.]. Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193418