Leptomeningeal Contrast Enhancement Is Associated with Disability Progression and Grey Matter Atrophy in Multiple Sclerosis
Joint Authors
Lapin, Sergey V.
Totolyan, Natalia
Makshakov, Gleb
Magonov, Evgeniy
Nazarov, Vladimir
Mazing, Alexandra
Verbitskaya, Elena
Trofimova, Tatiana
Krasnov, Vladimir
Shumilina, Maria
Skoromets, Alexander
Evdoshenko, Evgeniy
Source
Neurology Research International
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Leptomeningeal contrast enhancement (LMCE) on magnetic resonance imaging (MRI) is a newly recognized possible biomarker in multiple sclerosis (MS), associated with MS progression and cortical atrophy.
In this study, we aimed to assess the prevalence of LMCE foci and their impact on neurodegeneration and disability.
Materials.
54 patients with MS were included in the study.
LMCE were detected with a 3 Tesla scanner on postcontrast fluid-attenuated inversion-recovery (FLAIR) sequence.
Expanded Disability Status Scale (EDSS) score, number of relapses during 5 years from MS onset, and number of contrast-enhancing lesions on T1 weighted MRI were counted.
Results.
LMCE was detected in 41% (22/54) of patients.
LMCE-positive patients had longer disease duration (p=0,0098) and higher EDSS score (p=0,039), but not a higher relapse rate (p=0,091).
No association of LMCE with higher frequency of contrast-enhancing lesions on T1-weighted images was detected (p=0,3842).
Analysis of covariates, adjusted for age, sex, and disease duration, revealed a significant effect of LMCE on the cortex volume (p=0.043, F=2.529), the total grey matter volume (p=0.043, F=2.54), and total ventricular volume (p=0.039, F=2.605).
Conclusions.
LMCE was shown to be an independent and significant biomarker of grey matter atrophy and disability in MS.
American Psychological Association (APA)
Makshakov, Gleb& Magonov, Evgeniy& Totolyan, Natalia& Nazarov, Vladimir& Lapin, Sergey V.& Mazing, Alexandra…[et al.]. 2017. Leptomeningeal Contrast Enhancement Is Associated with Disability Progression and Grey Matter Atrophy in Multiple Sclerosis. Neurology Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1193426
Modern Language Association (MLA)
Makshakov, Gleb…[et al.]. Leptomeningeal Contrast Enhancement Is Associated with Disability Progression and Grey Matter Atrophy in Multiple Sclerosis. Neurology Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1193426
American Medical Association (AMA)
Makshakov, Gleb& Magonov, Evgeniy& Totolyan, Natalia& Nazarov, Vladimir& Lapin, Sergey V.& Mazing, Alexandra…[et al.]. Leptomeningeal Contrast Enhancement Is Associated with Disability Progression and Grey Matter Atrophy in Multiple Sclerosis. Neurology Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1193426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193426