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Mediators of Inflammation in Topical Therapy of Skin Cancers
Joint Authors
Căruntu, Constantin
Voiculescu, Vlad
Lupu, Mihai
Lisievici, Cristina
Solomon, Iulia
Vajaitu, Cristina
Draghici, Carmen Cristina
Constantin, Maria Magdalena
Popa, Alexandra Victoria
Sebe, Teona Ioana
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Taking into consideration that the immune system plays a very important role in the development of melanoma and non-melanoma skin cancers, which have a high prevalence in immunosuppressed patients and after prolonged ultraviolet radiation, the interest in developing novel therapies, in particular targeting the inflammation in cancer, has increased in the past years.
The latest data suggest that therapies such as imiquimod (IMQ), ingenol mebutate (IM), 5-fluorouracil (5-FU), retinoids, and nonsteroidal anti-inflammatory drugs (NSAIDs) have been used with success in the topical treatment of some cancers.
Herein, we review the topical treatment targeting the inflammation in skin cancer and the mechanisms involved in these processes.
Currently, various associations have shown a superior success rate than monotherapy, such as systemic acitretin and topical IMQ, topical 5-FU with tretinoin cream, or IMQ with checkpoint inhibitor cytotoxic T lymphocyte antigen 4.
Novel therapies targeting Toll-like receptor-7 (TLR-7) with higher selectivity than IMQ are also of great interest.
American Psychological Association (APA)
Voiculescu, Vlad& Lisievici, Cristina& Lupu, Mihai& Vajaitu, Cristina& Draghici, Carmen Cristina& Popa, Alexandra Victoria…[et al.]. 2019. Mediators of Inflammation in Topical Therapy of Skin Cancers. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1193452
Modern Language Association (MLA)
Voiculescu, Vlad…[et al.]. Mediators of Inflammation in Topical Therapy of Skin Cancers. Mediators of Inflammation No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1193452
American Medical Association (AMA)
Voiculescu, Vlad& Lisievici, Cristina& Lupu, Mihai& Vajaitu, Cristina& Draghici, Carmen Cristina& Popa, Alexandra Victoria…[et al.]. Mediators of Inflammation in Topical Therapy of Skin Cancers. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1193452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193452