Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus Erythematosus
Joint Authors
Haiyan, Zhou
Li, Bojiang
Li, Jing
Wu, Tongqian
Jin, Xiaoqian
Yuan, Rui
Shi, Ping
Zhou, Yan
Li, Long
Yu, Fang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Accumulating evidence indicates a critical role for T cells and relevant cytokines in the pathogenesis of systemic lupus erythematosus (SLE).
However, the specific contribution of T cells together with the related circulating cytokines in disease pathogenesis and organ involvement is still not clear.
In the current study, we investigated relevant molecule expressions and cytokine levels in blood samples from 49 SLE patients and 22 healthy control subjects.
The expression of HLA-DR and costimulatory molecules on T cells was evaluated by flow cytometry.
Concentrations of serum C-reactive protein, erythrocyte sedimentation rate, anti-double-stranded DNA (anti-dsDNA) antibody, total lgG, complement 3, and complement 4 were measured.
Serum cytokines and chemokines were measured by a cytometric bead array assay.
Elevated frequencies of HLA-DR+ T cells and ICOS+ T cells were observed in SLE patients with positive anti-dsDNA antibodies compared with those in healthy controls (P<0.001).
The expression of HLA-DR+ T cells was positively correlated with SLEDAI (r=0.15, P<0.01).
Furthermore, levels of serum IL-6, MCP-1, TNFRI, IL-10, IL-12, and CCL20 were higher in SLE patients compared with healthy controls.
In addition, patients with hematologic manifestations displayed elevated frequencies of HLA-DR+ T cells and ICOS+ T cells.
Patients with renal manifestations had a decreased frequency of TIGIT+ T cells.
These results suggested a dysregulated T cell activity and cytokine expression profiles in SLE subjects.
We also developed a chemokine and cytokine profiling strategy to predict the activity of SLE, which has clinical implication for better monitoring the flares and remission during the course of SLE and for assessing therapeutic interventions.
American Psychological Association (APA)
Haiyan, Zhou& Li, Bojiang& Li, Jing& Wu, Tongqian& Jin, Xiaoqian& Yuan, Rui…[et al.]. 2019. Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus Erythematosus. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1193483
Modern Language Association (MLA)
Haiyan, Zhou…[et al.]. Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus Erythematosus. Mediators of Inflammation No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1193483
American Medical Association (AMA)
Haiyan, Zhou& Li, Bojiang& Li, Jing& Wu, Tongqian& Jin, Xiaoqian& Yuan, Rui…[et al.]. Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus Erythematosus. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1193483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193483