Ceramide and IschemiaReperfusion Injury
Joint Authors
He, Xingxuan
Schuchman, Edward H.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ceramide, a bioactive membrane sphingolipid, functions as an important second messenger in apoptosis and cell signaling.
In response to stresses, it may be generated by de novo synthesis, sphingomyelin hydrolysis, and/or recycling of complex sphingolipids.
It is cleared from cells through the activity of ceramidases, phosphorylation to ceramide-1-phosphate, or resynthesis into more complex sphingolipids.
Ischemia/reperfusion (IR) injury occurs when oxygen/nutrition is rapidly reintroduced into ischemic tissue, resulting in cell death and tissue damage, and is a major concern in diverse clinical settings, including organ resection and transplantation.
Numerous reports show that ceramide levels are markedly elevated during IR.
Mitochondria are major sites of reactive oxygen species (ROS) production and play a key role in IR-induced and ceramide-mediated cell death and tissue damage.
During the development of IR injury, the initial response of ROS and TNF-alpha production activates two major ceramide generating pathways (sphingomyelin hydrolysis and de novo ceramide synthesis).
The increased ceramide has broad effects depending on the IR phases, including both pro- and antiapoptotic effects.
Therefore, strategies that reduce the levels of ceramide, for example, by modulation of ceramidase and/or sphingomyelinases activities, may represent novel and promising therapeutic approaches to prevent or treat IR injury in diverse clinical settings.
American Psychological Association (APA)
He, Xingxuan& Schuchman, Edward H.. 2018. Ceramide and IschemiaReperfusion Injury. Journal of Lipids،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1193493
Modern Language Association (MLA)
He, Xingxuan& Schuchman, Edward H.. Ceramide and IschemiaReperfusion Injury. Journal of Lipids No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1193493
American Medical Association (AMA)
He, Xingxuan& Schuchman, Edward H.. Ceramide and IschemiaReperfusion Injury. Journal of Lipids. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1193493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193493