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Intracellular and Plasma Membrane Events in Cholesterol Transport and Homeostasis
Joint Authors
Litvinov, Dmitry Y.
Savushkin, Eugeny V.
Dergunov, Alexander D.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-06
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Cholesterol transport between intracellular compartments proceeds by both energy- and non-energy-dependent processes.
Energy-dependent vesicular traffic partly contributes to cholesterol flux between endoplasmic reticulum, plasma membrane, and endocytic vesicles.
Membrane contact sites and lipid transfer proteins are involved in nonvesicular lipid traffic.
Only “active" cholesterol molecules outside of cholesterol-rich regions and partially exposed in water phase are able to fast transfer.
The dissociation of partially exposed cholesterol molecules in water determines the rate of passive aqueous diffusion of cholesterol out of plasma membrane.
ATP hydrolysis with concomitant conformational transition is required to cholesterol efflux by ABCA1 and ABCG1 transporters.
Besides, scavenger receptor SR-B1 is involved also in cholesterol efflux by facilitated diffusion via hydrophobic tunnel within the molecule.
Direct interaction of ABCA1 with apolipoprotein A-I (apoA-I) or apoA-I binding to high capacity binding sites in plasma membrane is important in cholesterol escape to free apoA-I.
ABCG1-mediated efflux to fully lipidated apoA-I within high density lipoprotein particle proceeds more likely through the increase of “active” cholesterol level.
Putative cholesterol-binding linear motifs within the structure of all three proteins ABCA1, ABCG1, and SR-B1 are suggested to contribute to the binding and transfer of cholesterol molecules from cytoplasmic to outer leaflets of lipid bilayer.
Together, plasma membrane events and intracellular cholesterol metabolism and traffic determine the capacity of the cell for cholesterol efflux.
American Psychological Association (APA)
Litvinov, Dmitry Y.& Savushkin, Eugeny V.& Dergunov, Alexander D.. 2018. Intracellular and Plasma Membrane Events in Cholesterol Transport and Homeostasis. Journal of Lipids،Vol. 2018, no. 2018, pp.1-22.
https://search.emarefa.net/detail/BIM-1193498
Modern Language Association (MLA)
Litvinov, Dmitry Y.…[et al.]. Intracellular and Plasma Membrane Events in Cholesterol Transport and Homeostasis. Journal of Lipids No. 2018 (2018), pp.1-22.
https://search.emarefa.net/detail/BIM-1193498
American Medical Association (AMA)
Litvinov, Dmitry Y.& Savushkin, Eugeny V.& Dergunov, Alexander D.. Intracellular and Plasma Membrane Events in Cholesterol Transport and Homeostasis. Journal of Lipids. 2018. Vol. 2018, no. 2018, pp.1-22.
https://search.emarefa.net/detail/BIM-1193498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193498