The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia

Abstract EN

Introduction.

Preeclampsia is a pregnancy-specific syndrome.

One of the hypotheses concerning the etiology of preeclampsia is vitamin D deficiency during pregnancy.

Method and Materials.

The present study is a randomized controlled clinical trial which aims to determine the effect of vitamin D supplement on reducing the probability of recurrent preeclampsia.

72 patients were placed in control group while 70 patients were randomized to the intervention group.

The intervention group received a 50000 IU pearl vitamin D3 once every two weeks.

The control group was administered placebo.

Vitamin D or placebo was given until the 36th week of pregnancy.

Results.

The patients in intervention group have significantly lower (P value = 0.036) probability of preeclampsia than patients in the control group.

The risk of preeclampsia for the control group was 1.94 times higher than that for the intervention group (95% CI 1.02, 3.71).

Conclusion.

The intended intervention (i.e., prescription of vitamin D) has a protective effect against recurrent preeclampsia.

Vitamin D supplementation therapy in pregnancy could help in reducing the incidence of gestational hypertension/preeclampsia.

Registration.

This study has been registered in Iranian Registry of Clinical Trials (IRCT) site with ID number IRCT2017010131695N1.