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The Prognostic Value of Baseline Lymphocyte, Neutrophil, and Monocyte Counts in Locally Advanced Cervical Carcinoma Treated with Radiation
Joint Authors
Himler, Justin
Nagel, Christa I.
Resnick, Kimberly
Singh, Sareena
Source
Obstetrics and Gynecology International
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
To determine the prognostic significance of pretreatment levels of circulating lymphocyte (CLC), neutrophil (CNC), and monocyte (CMC) counts in patients with locally advanced cervical carcinoma (CC) treated with definitive radiation.
Methods.
A retrospective, dual-institution review of patients with Stage IB2-IVA CC from 2005 to 2015.
Progression-free (PFS) and Overall Survival (OS) were determined for high and low CLC, CNC, and CMC groups.
Multivariate analysis was used to confirm prognostic value of baseline leukocyte counts.
Results.
181 patients were included.
Median follow-up time was 26 (3–89) months.
CNC had no effect on PFS or OS.
PFS was similar between CMC groups; however, OS was significantly improved for patients with low CMC (62.5 versus 45.3 months, p=0.016).
High CLC was associated with improved PFS (48.5 versus 27.8 months, p=0.048) and OS (58.4 versus 34.9 months, p=0.048).
On multivariate analysis, high CNC was associated with increased relapse risk (HR 1.12, p=0.006) and low CLC was associated with increased mortality risk (HR 0.67, p=0.027).
Conclusion.
This study demonstrates that leukocyte values can provide prognostic information in CC.
These hypothesis-generating findings warrant further prospective investigations.
American Psychological Association (APA)
Singh, Sareena& Himler, Justin& Nagel, Christa I.& Resnick, Kimberly. 2017. The Prognostic Value of Baseline Lymphocyte, Neutrophil, and Monocyte Counts in Locally Advanced Cervical Carcinoma Treated with Radiation. Obstetrics and Gynecology International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1193525
Modern Language Association (MLA)
Singh, Sareena…[et al.]. The Prognostic Value of Baseline Lymphocyte, Neutrophil, and Monocyte Counts in Locally Advanced Cervical Carcinoma Treated with Radiation. Obstetrics and Gynecology International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1193525
American Medical Association (AMA)
Singh, Sareena& Himler, Justin& Nagel, Christa I.& Resnick, Kimberly. The Prognostic Value of Baseline Lymphocyte, Neutrophil, and Monocyte Counts in Locally Advanced Cervical Carcinoma Treated with Radiation. Obstetrics and Gynecology International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1193525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193525