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Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications
Joint Authors
Chiorcea-Paquim, Ana-Maria
Oliveira-Brett, Ana Maria
Eritja, Ramon
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Guanine-rich DNA sequences are able to form G-quadruplexes, being involved in important biological processes and representing smart self-assembling nanomaterials that are increasingly used in DNA nanotechnology and biosensor technology.
G-quadruplex electrochemical biosensors have received particular attention, since the electrochemical response is particularly sensitive to the DNA structural changes from single-stranded, double-stranded, or hairpin into a G-quadruplex configuration.
Furthermore, the development of an increased number of G-quadruplex aptamers that combine the G-quadruplex stiffness and self-assembling versatility with the aptamer high specificity of binding to a variety of molecular targets allowed the construction of biosensors with increased selectivity and sensitivity.
This review discusses the recent advances on the electrochemical characterization, design, and applications of G-quadruplex electrochemical biosensors in the evaluation of metal ions, G-quadruplex ligands, and other small organic molecules, proteins, and cells.
The electrochemical and atomic force microscopy characterization of G-quadruplexes is presented.
The incubation time and cations concentration dependence in controlling the G-quadruplex folding, stability, and nanostructures formation at carbon electrodes are discussed.
Different G-quadruplex electrochemical biosensors design strategies, based on the DNA folding into a G-quadruplex, the use of G-quadruplex aptamers, or the use of hemin/G-quadruplex DNAzymes, are revisited.
American Psychological Association (APA)
Chiorcea-Paquim, Ana-Maria& Eritja, Ramon& Oliveira-Brett, Ana Maria. 2018. Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications. Journal of Nucleic Acids،Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1193615
Modern Language Association (MLA)
Chiorcea-Paquim, Ana-Maria…[et al.]. Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications. Journal of Nucleic Acids No. 2018 (2018), pp.1-20.
https://search.emarefa.net/detail/BIM-1193615
American Medical Association (AMA)
Chiorcea-Paquim, Ana-Maria& Eritja, Ramon& Oliveira-Brett, Ana Maria. Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications. Journal of Nucleic Acids. 2018. Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1193615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193615