Cardiac Nonmyocyte Cell Functions and Crosstalks in Response to Cardiotoxic Drugs
Joint Authors
Iaccarino, G.
Sorriento, Daniela
Trimarco, Bruno
Gambardella, Jessica
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The discovery of the molecular mechanisms involved in the cardiac responses to anticancer drugs represents the current goal of cardio-oncology research.
The oxidative stress has a pivotal role in cardiotoxic responses, affecting the function of all types of cardiac cells, and their functional crosstalks.
Generally, cardiomyocytes are the main target of research studies on cardiotoxicity, but recently the contribution of the other nonmyocyte cardiac cells is becoming of growing interest.
This review deals with the role of oxidative stress, induced by anticancer drugs, in cardiac nonmyocyte cells (fibroblasts, vascular cells, and immune cells).
The alterations of functional interplays among these cardiac cells are discussed, as well.
These interesting recent findings increase the knowledge about cardiotoxicity and suggest new molecular targets for both diagnosis and therapy.
American Psychological Association (APA)
Gambardella, Jessica& Trimarco, Bruno& Iaccarino, G.& Sorriento, Daniela. 2017. Cardiac Nonmyocyte Cell Functions and Crosstalks in Response to Cardiotoxic Drugs. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193694
Modern Language Association (MLA)
Gambardella, Jessica…[et al.]. Cardiac Nonmyocyte Cell Functions and Crosstalks in Response to Cardiotoxic Drugs. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193694
American Medical Association (AMA)
Gambardella, Jessica& Trimarco, Bruno& Iaccarino, G.& Sorriento, Daniela. Cardiac Nonmyocyte Cell Functions and Crosstalks in Response to Cardiotoxic Drugs. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193694