Antimicrobial Silver-Polyethyleneimine-Polylactic Acid Polymer Composite Film for Coating Methacrylate-Based Denture Surfaces
Joint Authors
Géczi, Zoltán
Hermann, Péter
Kőhidai, László
Láng, Orsolya
Kőhidai, Zsófia
Mészáros, Tamás
Barócsi, Attila
Lenk, Sándor
Zelles, Tivadar
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To prepare an antimicrobial polymer composite composed of silver- (Ag-) polyethyleneimine- (PEI-) polylactic acid (PLA) in chloroform, for coating the mucosal surfaces of methacrylate-based dentures as a prospective therapy for denture stomatitis.
The water-insoluble, tightly bound, hard, micrometre-thin, and colourless film exerts its effects by direct contact with the pathogens and via the active constituents (Ag, PEI, and Ag-PEI) released slowly into the mucosa’s salivary layer.
Silver and PEI were blended at 140°C, then bound to PLA.
The Ag-PEI complex was characterised by dynamic light scattering and transmission electron microscopy, and the Ag-PEI-PLA composite was examined by atomic force microscopy and micro-computed tomography.
The characteristic was measured by atomic force microscopy (AFM) and micro-computed tomography (micro-CT).
The quantity of water-soluble Ag-PEI complex released from the composite film was measured with gravimetry.
The cellular physiological effects were analysed by impedimetry and computer-based morphometry using human gingival epithelial cells.
A real-time cell proliferation assay revealed moderate toxic effects of Ag-PEI on the epithelium.
The viscous Ag-PEI-PLA solution produced could be applied as a thin film on methacrylate surfaces.
Active antimicrobial components (Ag, PEI, and Ag-PEI) were released from the hard, tightly bound Ag-PEI-PLA coating.
This study’s findings verified the applicability of the antimicrobial Ag-PEI-PLA composite for coating the inner surfaces of acrylate dentures.
Owing to the well-known antimicrobial effects of silver and PEI and the supplementary effects of chloroform, this composite provides a new therapeutic method for denture stomatitis that can be easily performed by dentists.
American Psychological Association (APA)
Géczi, Zoltán& Hermann, Péter& Kőhidai, László& Láng, Orsolya& Kőhidai, Zsófia& Mészáros, Tamás…[et al.]. 2018. Antimicrobial Silver-Polyethyleneimine-Polylactic Acid Polymer Composite Film for Coating Methacrylate-Based Denture Surfaces. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1193695
Modern Language Association (MLA)
Géczi, Zoltán…[et al.]. Antimicrobial Silver-Polyethyleneimine-Polylactic Acid Polymer Composite Film for Coating Methacrylate-Based Denture Surfaces. Journal of Nanomaterials No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1193695
American Medical Association (AMA)
Géczi, Zoltán& Hermann, Péter& Kőhidai, László& Láng, Orsolya& Kőhidai, Zsófia& Mészáros, Tamás…[et al.]. Antimicrobial Silver-Polyethyleneimine-Polylactic Acid Polymer Composite Film for Coating Methacrylate-Based Denture Surfaces. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1193695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193695