Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats
Joint Authors
Al-Rasheed, Nouf M.
Mohamad, Raeesa A.
Al-Rasheed, Nawal M.
Mahmoud, Ayman M.
Hasan, Iman H.
Al-Amin, Maha A.
Al-Ajmi, Hanaa N.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Simvastatin is a lipid-lowering agent used to treat hypercholesterolemia and to reduce the risk of heart disease.
This study scrutinized the beneficial effects of simvastatin on experimental diabetic cardiomyopathy (DCM), pointing to the role of hyperglycemia-induced oxidative stress and inflammation.
Diabetes was induced by intraperitoneal injection of streptozotocin and both control and diabetic rats received simvastatin for 90 days.
Diabetic rats showed significant cardiac hypertrophy, body weight loss, hyperglycemia, and hyperlipidemia.
Serum creatine kinase MB (CK-MB) and troponin I showed a significant increase in diabetic rats.
Simvastatin significantly improved body weight, attenuated hyperglycemia and hyperlipidemia, and ameliorated CK-MB and troponin I.
Simvastatin prevented histological alterations and deposition of collagen in the heart of diabetic animals.
Lipid peroxidation and nitric oxide were increased in the heart of diabetic rats whereas antioxidant defenses were decreased.
These alterations were significantly reversed by simvastatin.
In addition, simvastatin decreased serum inflammatory mediators and expression of NF-κB in the diabetic heart.
Cardiac caspase-3 was increased in the diabetic heart and decreased following treatment with simvastatin.
In conclusion, our results suggest that simvastatin alleviates DCM by attenuating hyperglycemia/hyperlipidemia-induced oxidative stress, inflammation, and apoptosis.
American Psychological Association (APA)
Al-Rasheed, Nawal M.& Al-Rasheed, Nouf M.& Hasan, Iman H.& Al-Amin, Maha A.& Al-Ajmi, Hanaa N.& Mohamad, Raeesa A.…[et al.]. 2017. Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1193709
Modern Language Association (MLA)
Al-Rasheed, Nawal M.…[et al.]. Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1193709
American Medical Association (AMA)
Al-Rasheed, Nawal M.& Al-Rasheed, Nouf M.& Hasan, Iman H.& Al-Amin, Maha A.& Al-Ajmi, Hanaa N.& Mohamad, Raeesa A.…[et al.]. Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1193709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193709