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A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery
Joint Authors
Wang, Xin
Gao, Ziyu
Zhang, Long
Wang, Huiming
Zhang, Guojun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Mild acid response nanocarriers have been intensively attracted interest in the field of drug delivery on the account of the responsive property to abnormal physiological environment as well as the original property to normal physiological environment.
However, the drug delivery system lacks capacity of precise localization to abnormal tissue or targeted cells.
Therefore, a magnetic and pH-sensitive composite nanoparticle was designed and prepared by double water-in-oil-in-water (W/O/W) emulsion using acetylated β-cyclodextrin (Ac-β-CD) as a dominant material to realize the pH response and Fe3O4 as a component to realize magnetic response.
The surface chemical characteristic was characterized by Fourier-transformed infrared spectroscopy (FTIR) using pure Ac-β-CD nanoparticle as a control and exhibits the typical chemical characteristic of Ac-β-CD.
Furthermore, the structural information was tracked by X-ray diffraction (XRD) and thermogravimetric analysis (TG).
It was found that composite nanoparticle possessed structural characteristic of both Ac-β-CD and Fe3O4.
Composite nanoparticle exhibited sphere and two-phase morphology with the diameter of about 200–250 nm depending on their detection method and zeta potential of −12 to −14 mV.
More importantly, irreversible pH response property and reversible magnetic responsive properties either in neutral environment or in mild acid environment for the composite nanoparticle were confirmed in the research.
Finally, drug loading and release behavior were investigated through preliminary in vitro evaluation.
American Psychological Association (APA)
Wang, Xin& Gao, Ziyu& Zhang, Long& Wang, Huiming& Zhang, Guojun. 2018. A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1193730
Modern Language Association (MLA)
Wang, Xin…[et al.]. A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery. Journal of Nanomaterials No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1193730
American Medical Association (AMA)
Wang, Xin& Gao, Ziyu& Zhang, Long& Wang, Huiming& Zhang, Guojun. A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1193730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193730