High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation
Joint Authors
Thorin, Eric
Thorin-Trescases, Nathalie
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family.
ANGPTL2 is secreted and detected in the systemic circulation.
Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers.
However, these studies did not address the following questions: (a) what are the sources of circulating ANGPTL2? (b) How and by which mechanisms an increase in circulating ANGPTL2 contributes to the pathogenesis of chronic inflammatory diseases? (c) Does an increase in circulating levels of ANGPTL2 measured in a well-defined chronic medical condition originate from a specific cell type? Mechanistic hypotheses have been proposed based on studies performed in mice and cultured cells, and proinflammatory, prooxidative, proangiogenic, proliferative, and antiapoptotic properties of ANGPTL2 have been reported.
The aim of this review is to propose answers concerning the potential sources of circulating ANGPTL2 and its common pathological properties associated with various chronic inflammatory diseases and death in humans.
We believe that high circulating ANGPTL2 levels are more than an inflammatory marker and may reflect the senescent cellular load of an individual.
American Psychological Association (APA)
Thorin-Trescases, Nathalie& Thorin, Eric. 2017. High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193739
Modern Language Association (MLA)
Thorin-Trescases, Nathalie& Thorin, Eric. High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193739
American Medical Association (AMA)
Thorin-Trescases, Nathalie& Thorin, Eric. High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193739