Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases
Joint Authors
Ivanova, Ekaterina A.
Myasoedova, Veronika A.
Grechko, Andrey V.
Orekhov, Alexander N.
Melnichenko, Alexandra A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Low-density lipoprotein (LDL) plays a key role in the development and progression of atherosclerosis and cardiovascular disease.
LDL consists of several subclasses of particles with different sizes and densities, including large buoyant (lb) and intermediate and small dense (sd) LDLs.
It has been well documented that sdLDL has a greater atherogenic potential than that of other LDL subfractions and that sdLDL cholesterol (sdLDL-C) proportion is a better marker for prediction of cardiovascular disease than that of total LDL-C.
Circulating sdLDL readily undergoes multiple atherogenic modifications in blood plasma, such as desialylation, glycation, and oxidation, that further increase its atherogenicity.
Modified sdLDL is a potent inductor of inflammatory processes associated with cardiovascular disease.
Several laboratory methods have been developed for separation of LDL subclasses, and the results obtained by different methods can not be directly compared in most cases.
Recently, the development of homogeneous assays facilitated the LDL subfraction analysis making possible large clinical studies evaluating the significance of sdLDL in the development of cardiovascular disease.
Further studies are needed to establish guidelines for sdLDL evaluation and correction in clinical practice.
American Psychological Association (APA)
Ivanova, Ekaterina A.& Myasoedova, Veronika A.& Melnichenko, Alexandra A.& Grechko, Andrey V.& Orekhov, Alexander N.. 2017. Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193765
Modern Language Association (MLA)
Ivanova, Ekaterina A.…[et al.]. Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1193765
American Medical Association (AMA)
Ivanova, Ekaterina A.& Myasoedova, Veronika A.& Melnichenko, Alexandra A.& Grechko, Andrey V.& Orekhov, Alexander N.. Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193765