Multifunctional Amine Mesoporous Silica Spheres Modified with Multiple Amine as Carriers for Drug Release
Joint Authors
Li, Yan
Song, Fangxiang
Guo, Yu
Cheng, Liang
Chen, Qianlin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mesoporous silica spheres were synthesized by using Stöber theory (MSN-40).
Calcination of the mesostructured phase resulted in the starting solid.
Organic modification with aminopropyl groups resulted in two MSN-40 materials: named MSN-NH2 and MSN-DQ-40, respectively.
These two kinds of samples with different pore sizes (obtained from 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethox-ysilane (NQ-62) and modified NQ-62) showed control of the delivery rate of ibuprofen (IBU) from the siliceous matrix.
The obtained sample from modified NQ-62 has an increased loading rate and shows better control of the delivery rate of IBU than the obtained sample from NQ-62.
These three solids were characterized using standard solid state procedures.
During tests of in vitro drug release, an interesting phenomenon was observed: at high pH (pH 7.45), IBU in all carriers was released slowly; at low pH (pH 4.5), only a part of the IBU was slowly released from this carrier within 25 hours; most IBU was effectively confined in mesoporous material, but the remaining IBU was released rapidly and completely after 25 hours.
American Psychological Association (APA)
Li, Yan& Song, Fangxiang& Guo, Yu& Cheng, Liang& Chen, Qianlin. 2018. Multifunctional Amine Mesoporous Silica Spheres Modified with Multiple Amine as Carriers for Drug Release. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1193818
Modern Language Association (MLA)
Li, Yan…[et al.]. Multifunctional Amine Mesoporous Silica Spheres Modified with Multiple Amine as Carriers for Drug Release. Journal of Nanomaterials No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1193818
American Medical Association (AMA)
Li, Yan& Song, Fangxiang& Guo, Yu& Cheng, Liang& Chen, Qianlin. Multifunctional Amine Mesoporous Silica Spheres Modified with Multiple Amine as Carriers for Drug Release. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1193818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193818