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Icariin-Loaded TiO2 Nanotubes for Regulation of the Bioactivity of Bone Marrow Cells
Joint Authors
Zhang, Yanli
Liu, Chundong
Chen, Liangjiao
Chen, Aijie
Feng, Xiaoli
Shao, Longquan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
To explore the effects of icariin on the biocompatibility of dental implants, icariin- (ICA-) loaded TiO2 nanotubes were fabricated on Ti substrates via anodic oxidation and physical absorption.
The surface characteristics of the specimens were monitored by field emission scanning electron microscopy (FE-SEM), X-ray diffractometry (XRD), contact angle measurements (CA), and high-pressure liquid chromatography.
Additionally, the activities of bone marrow cells, such as cytoskeletal, proliferative activities, mineralization, and osteogenesis-related gene expression on the substrates were investigated in detail.
The characterization results demonstrated that ICA-loaded TiO2 nanotubes were successfully fabricated and the hydrophilicity of these TiO2 nanotubes was significantly higher than that of the pure Ti groups.
The results also showed that ICA-loaded TiO2 nanotubes might not have enhanced effects on cell proliferation and ALP expression.
However, it seemed to significantly promote differentiation of bone marrow cells, demonstrated by enhancing the formation of mineralized nodule and the upregulation of the gene expression such as OC, BSP, OPN, and COL-1.
The results indicated that ICA-loaded TiO2 nanotubes can modulate bioactivity of bone marrow cells, which is promising for potential applications in the orthopedics field.
American Psychological Association (APA)
Zhang, Yanli& Liu, Chundong& Chen, Liangjiao& Chen, Aijie& Feng, Xiaoli& Shao, Longquan. 2018. Icariin-Loaded TiO2 Nanotubes for Regulation of the Bioactivity of Bone Marrow Cells. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193826
Modern Language Association (MLA)
Zhang, Yanli…[et al.]. Icariin-Loaded TiO2 Nanotubes for Regulation of the Bioactivity of Bone Marrow Cells. Journal of Nanomaterials No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1193826
American Medical Association (AMA)
Zhang, Yanli& Liu, Chundong& Chen, Liangjiao& Chen, Aijie& Feng, Xiaoli& Shao, Longquan. Icariin-Loaded TiO2 Nanotubes for Regulation of the Bioactivity of Bone Marrow Cells. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193826