Exercise Training Restores Cardiac MicroRNA-1 and MicroRNA-29c to Nonpathological Levels in Obese Rats
Joint Authors
Oliveira, Edilamar Menezes de
Silveira, André C.
Fernandes, Tiago
Soci, Úrsula P. R.
Gomes, João L. P.
Barretti, Diego L.
Mota, Glória G. F.
Negrão, Carlos Eduardo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We previously reported that aerobic exercise training (AET) consisted of 10 weeks of 60-min swimming sessions, and 5 days/week AET counteracts CH in obesity.
Here, we evaluated the role of microRNAs and their target genes that are involved in heart collagen deposition and calcium signaling, as well as the cardiac remodeling induced by AET in obese Zucker rats.
Among the four experimental Zucker groups: control lean rats (LZR), control obese rats (OZR), trained lean rats (LZR + TR), and trained obese rats (OZR + TR), heart weight was greater in the OZR than in the LZR group due to increased cardiac intramuscular fat and collagen.
AET seems to exert a protective role in normalizing the heart weight in the OZR + TR group.
Cardiac microRNA-29c expression was decreased in OZR compared with the LZR group, paralleled by an increase in the collagen volumetric fraction (CVF).
MicroRNA-1 expression was upregulated while the expression of its target gene NCX1 was decreased in OZR compared with the LZR group.
Interestingly, AET restored cardiac microRNA-1 to nonpathological levels in the OZR-TR group.
Our findings suggest that AET could be used as a nonpharmacological therapy for the reversal of pathological cardiac remodeling and cardiac dysfunction in obesity.
American Psychological Association (APA)
Silveira, André C.& Fernandes, Tiago& Soci, Úrsula P. R.& Gomes, João L. P.& Barretti, Diego L.& Mota, Glória G. F.…[et al.]. 2017. Exercise Training Restores Cardiac MicroRNA-1 and MicroRNA-29c to Nonpathological Levels in Obese Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193857
Modern Language Association (MLA)
Silveira, André C.…[et al.]. Exercise Training Restores Cardiac MicroRNA-1 and MicroRNA-29c to Nonpathological Levels in Obese Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193857
American Medical Association (AMA)
Silveira, André C.& Fernandes, Tiago& Soci, Úrsula P. R.& Gomes, João L. P.& Barretti, Diego L.& Mota, Glória G. F.…[et al.]. Exercise Training Restores Cardiac MicroRNA-1 and MicroRNA-29c to Nonpathological Levels in Obese Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193857