DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases
Joint Authors
Bin, Peng
Yin, Yulong
Ren, Wenkai
Wang, Tianwei
Zhong, Jin
Liang, Jun
Hu, Chien-An Andy
Zeng, Zhaoying
Liu, Gang-yu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Patients suffering from cardiovascular diseases (CVDs) experience a low quality of life and increase pressure on healthcare systems both nationally and globally.
DNA methylation, which refers to the pathway by which DNA methyltransferase facilitates the addition of a methyl group to DNA, is of critical importance in this respect primarily because the epigenetic modification is implicated in a range of serious conditions including atherosclerosis, CVDs, and cancer.
Research findings indicate that the number of epigenetic alterations can be elicited (both in utero and in adults) through the administration of certain nutritional supplements, including folic acid and methionine; this is partly attributable to the effect employed by methyl-containing nutrients in DNA methylation.
Thus, for the purpose of illuminating viable therapeutic measures and preventive strategies for CVDs, research should continue to explore the intricate associations that exist between epigenetic regulation and CVD pathogenesis.
This review centers on an exposition of the mechanism by which DNA methylation takes place, the impact it has on a range of conditions, and the potential clinical value of nutrition, driven mainly by the observation that nutritional supplements such as folic acid can affect DNA methylation.
American Psychological Association (APA)
Liu, Gang-yu& Bin, Peng& Wang, Tianwei& Ren, Wenkai& Zhong, Jin& Liang, Jun…[et al.]. 2017. DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1193888
Modern Language Association (MLA)
Liu, Gang-yu…[et al.]. DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1193888
American Medical Association (AMA)
Liu, Gang-yu& Bin, Peng& Wang, Tianwei& Ren, Wenkai& Zhong, Jin& Liang, Jun…[et al.]. DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1193888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193888