![](/images/graphics-bg.png)
Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells
Joint Authors
Kannan, Ram
Minasyan, Leonid
Sreekumar, Parameswaran G.
Hinton, David R.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Age-related macular degeneration (AMD) is the leading cause of severe and irreversible vision loss and is characterized by progressive degeneration of the retina resulting in loss of central vision.
The retinal pigment epithelium (RPE) is a critical site of pathology of AMD.
Mitochondria and the endoplasmic reticulum which lie in close anatomic proximity to each other are targets of oxidative stress and endoplasmic reticulum (ER) stress, respectively, and contribute to the progression of AMD.
The two organelles exhibit close interactive function via various signaling mechanisms.
Evidence for ER-mitochondrial crosstalk in RPE under ER stress and signaling pathways of apoptotic cell death is presented.
The role of humanin (HN), a prominent member of a newly discovered family of mitochondrial-derived peptides (MDPs) expressed from an open reading frame of mitochondrial 16S rRNA, in modulation of ER and oxidative stress in RPE is discussed.
HN protected RPE cells from oxidative and ER stress-induced cell death by upregulation of mitochondrial GSH, inhibition of ROS generation, and caspase 3 and 4 activation.
The underlying mechanisms of ER-mitochondrial crosstalk and modulation by exogenous HN are discussed.
The therapeutic use of HN and related MDPs could potentially prove to be a valuable approach for treatment of AMD.
American Psychological Association (APA)
Minasyan, Leonid& Sreekumar, Parameswaran G.& Hinton, David R.& Kannan, Ram. 2017. Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193893
Modern Language Association (MLA)
Minasyan, Leonid…[et al.]. Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1193893
American Medical Association (AMA)
Minasyan, Leonid& Sreekumar, Parameswaran G.& Hinton, David R.& Kannan, Ram. Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193893