Effect of Emodin on Preventing Postoperative Intra-Abdominal Adhesion Formation
Joint Authors
Li, Xuqi
Zhou, Cancan
Wang, Guanghui
Wang, Kang
Wei, Guangbing
Wu, Yunhua
Gao, Qi
Wang, Kai
Shen, Cong
Sun, Xuejun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Postoperative intra-abdominal adhesions are a major complication after abdominal surgery.
Although various methods have been used to prevent and treat adhesions, the effects have not been satisfactory.
Emodin, a naturally occurring anthraquinone derivative and an active ingredient in traditional Chinese herbs, exhibits a variety of pharmacological effects.
In our study, we demonstrated the effect of emodin treatment on preventing postoperative adhesion formation.
Materials and Methods.
A total of 48 rats were divided into six groups.
Abdominal adhesions were created by abrasion of the cecum and its opposite abdominal wall.
In the experimental groups, the rats were administered daily oral doses of emodin.
On the seventh day after operation, the rats were euthanized, and blood and pathological specimens were collected.
Abdominal adhesion formation was evaluated by necropsy, pathology, immunohistochemistry, Western blot, and enzyme-linked immunosorbent assay analyses.
Results.
Abdominal adhesions were markedly reduced by emodin treatment.
Compared with the control group, collagen deposition was reduced and the peritoneal mesothelial completeness rate was higher in the emodin-treated groups.
Emodin had anti-inflammatory effects, reduced oxidative stress, and promoted the movement of the intestinal tract (P<0.05).
Conclusion.
Emodin significantly reduced intra-abdominal adhesion formation in a rat model.
American Psychological Association (APA)
Wei, Guangbing& Wu, Yunhua& Gao, Qi& Zhou, Cancan& Wang, Kai& Shen, Cong…[et al.]. 2017. Effect of Emodin on Preventing Postoperative Intra-Abdominal Adhesion Formation. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193934
Modern Language Association (MLA)
Wei, Guangbing…[et al.]. Effect of Emodin on Preventing Postoperative Intra-Abdominal Adhesion Formation. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193934
American Medical Association (AMA)
Wei, Guangbing& Wu, Yunhua& Gao, Qi& Zhou, Cancan& Wang, Kai& Shen, Cong…[et al.]. Effect of Emodin on Preventing Postoperative Intra-Abdominal Adhesion Formation. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193934