Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells
Joint Authors
Wang, Shouju
Wang, Kun
Chen, Kun
Zhao, Yijing
Ma, Xingqun
Wang, Lin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Anaplastic thyroid cancer (ATC) is highly aggressive and tends to develop drug resistance to standard chemotherapies.
To overcome the drug resistance of ATC, we synthesized dopamine-melanin nanoparticles (MNPs) loaded with doxorubicin (Dox) molecules.
The Dox-loaded MNPs (Dox-MNPs) developed exhibited increased cellular uptake and enhanced therapeutic efficacy in drug-resistant ATC cell line HTh74R, compared with free Dox.
The native MNPs were found to have excellent biocompatibility, which suggests that Dox-MNPs may have potential in the treatment of ATC.
American Psychological Association (APA)
Wang, Kun& Wang, Shouju& Chen, Kun& Zhao, Yijing& Ma, Xingqun& Wang, Lin. 2018. Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1193938
Modern Language Association (MLA)
Wang, Kun…[et al.]. Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells. Journal of Nanomaterials No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1193938
American Medical Association (AMA)
Wang, Kun& Wang, Shouju& Chen, Kun& Zhao, Yijing& Ma, Xingqun& Wang, Lin. Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1193938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193938
