Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals
Joint Authors
Garcia-Rivas, Gerardo
Treviño-Saldaña, Niria
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-06
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Modulation of posttranslational modifications (PTMs), such as protein acetylation, is considered a novel therapeutic strategy to combat the development and progression of cardiovascular diseases.
Protein hyperacetylation is associated with the development of numerous cardiovascular diseases, including atherosclerosis, hypertension, cardiac hypertrophy, and heart failure.
In addition, decreased expression and activity of the deacetylases Sirt1, Sirt3, and Sirt6 have been linked to the development and progression of cardiac dysfunction.
Several phytochemicals exert cardioprotective effects by regulating protein acetylation levels.
These effects are mainly exerted via activation of Sirt1 and Sirt3 and inhibition of acetyltransferases.
Numerous studies support a cardioprotective role for sirtuin activators (e.g., resveratrol), as well as other emerging modulators of protein acetylation, including curcumin, honokiol, oroxilyn A, quercetin, epigallocatechin-3-gallate, bakuchiol, tyrosol, and berberine.
Studies also point to a cardioprotective role for various nonaromatic molecules, such as docosahexaenoic acid, alpha-lipoic acid, sulforaphane, and caffeic acid ethanolamide.
Here, we review the vast evidence from the bench to the clinical setting for the potential cardioprotective roles of various phytochemicals in the modulation of sirtuin-mediated deacetylation.
American Psychological Association (APA)
Treviño-Saldaña, Niria& Garcia-Rivas, Gerardo. 2017. Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1193939
Modern Language Association (MLA)
Treviño-Saldaña, Niria& Garcia-Rivas, Gerardo. Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1193939
American Medical Association (AMA)
Treviño-Saldaña, Niria& Garcia-Rivas, Gerardo. Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1193939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193939