Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cytoplasmic stress granules (SGs) are critical for facilitating stress responses and for preventing the accumulation of misfolded proteins.
SGs, however, have been linked to the pathogenesis of neurodegenerative diseases, in part because SGs share many components with neuronal granules.
Oxidative stress is one of the conditions that induce SG formation.
SGs regulate redox levels, and SG formation in turn is differently regulated by various types of oxidative stress.
These associations and other evidences suggest that SG formation contributes to the development of neurodegenerative diseases.
In this paper, we review the regulation of SG formation/assembly and discuss the interactions between oxidative stress and SG formation.
We then discuss the links between SGs and neurodegenerative diseases and the current therapeutic approaches for neurodegenerative diseases that target SGs.
American Psychological Association (APA)
Chen, Lihua& Liu, Beidong. 2017. Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193944
Modern Language Association (MLA)
Chen, Lihua& Liu, Beidong. Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1193944
American Medical Association (AMA)
Chen, Lihua& Liu, Beidong. Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193944