Increased Circulating Levels of Interleukin-6 Induce Perturbation in Redox-Regulated Signaling Cascades in Muscle of Dystrophic Mice
Joint Authors
Musarò, Antonio
Forcina, Laura
Nicoletti, Carmine
Scicchitano, Bianca Maria
Pelosi, Laura
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Duchenne muscular dystrophy (DMD) is an X-linked genetic disease in which dystrophin gene is mutated, resulting in dysfunctional or absent dystrophin protein.
The pathology of dystrophic muscle includes degeneration, necrosis with inflammatory cell invasion, regeneration, and fibrous and fatty changes.
Nevertheless, the mechanisms by which the absence of dystrophin leads to muscle degeneration remain to be fully elucidated.
An imbalance between oxidant and antioxidant systems has been proposed as a secondary effect of DMD.
However, the significance and precise extent of the perturbation in redox signaling cascades is poorly understood.
We report that mdx dystrophic mice are able to activate a compensatory antioxidant response at the presymptomatic stage of the disease.
In contrast, increased circulating levels of IL-6 perturb the redox signaling cascade, even prior to the necrotic stage, leading to severe features and progressive nature of muscular dystrophy.
American Psychological Association (APA)
Pelosi, Laura& Forcina, Laura& Nicoletti, Carmine& Scicchitano, Bianca Maria& Musarò, Antonio. 2017. Increased Circulating Levels of Interleukin-6 Induce Perturbation in Redox-Regulated Signaling Cascades in Muscle of Dystrophic Mice. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193982
Modern Language Association (MLA)
Pelosi, Laura…[et al.]. Increased Circulating Levels of Interleukin-6 Induce Perturbation in Redox-Regulated Signaling Cascades in Muscle of Dystrophic Mice. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1193982
American Medical Association (AMA)
Pelosi, Laura& Forcina, Laura& Nicoletti, Carmine& Scicchitano, Bianca Maria& Musarò, Antonio. Increased Circulating Levels of Interleukin-6 Induce Perturbation in Redox-Regulated Signaling Cascades in Muscle of Dystrophic Mice. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193982