Absorption and Elimination of Oat Avenanthramides in Humans after Acute Consumption of Oat Cookies
Joint Authors
Ji, Li Li
Zhang, Tianou
Shao, Jing
Gao, Yike
Chen, Chi
Yao, Dan
Chu, Yi Fang
Johnson, Jodee
Kang, Chounghun
Yeo, Dongwook
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Avenanthramides (AVA) are a group of diphenolic acids found only in oats that have anti-inflammatory and antioxidant effects.
Absorption of AVAs in humans after oral consumption of natural oat flour is unknown.
Objective.
To examine the appearance of AVAs in plasma after oral ingestion of oat cookies and estimate key pharmacokinetic parameters.
Methods.
Male and female nonobese participants (n=16) consumed three cookies made with oat flour containing high (229.6 mg/kg, H-AVA) or low (32.7 mg/kg, L-AVA) amounts of AVAs, including AVA-A, AVA-B, and AVA-C.
Blood samples were collected at 0, 0.5, 1, 2, 3, 5, and 10 h after ingestion.
Plasma total (conjugated and free) AVA concentrations were quantified using UPLC-MS, and pharmacokinetic parameters for each AVA were estimated.
Results.
AVAs reached peak concentrations in plasma between 2 and 3 h for the H-AVA group and between 1 and 2 h for the L-AVA group.
Maximal plasma concentrations for AVAs were higher in the H-AVA than in the L-AVA group.
AVA-B demonstrated a longer half-life and slower elimination rate than AVA-A and AVA-C.
Conclusions.
AVAs found naturally in oats are absorbed in the plasma after oral administration in humans.
AVA-B has the slowest elimination rate and the longest half-life compared to AVA-A and AVA-C, while AVA-C demonstrated the lowest plasma concentrations.
This study is registered with ClinicalTrials.gov identifier NCT02415374.
American Psychological Association (APA)
Zhang, Tianou& Shao, Jing& Gao, Yike& Chen, Chi& Yao, Dan& Chu, Yi Fang…[et al.]. 2017. Absorption and Elimination of Oat Avenanthramides in Humans after Acute Consumption of Oat Cookies. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1193985
Modern Language Association (MLA)
Zhang, Tianou…[et al.]. Absorption and Elimination of Oat Avenanthramides in Humans after Acute Consumption of Oat Cookies. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1193985
American Medical Association (AMA)
Zhang, Tianou& Shao, Jing& Gao, Yike& Chen, Chi& Yao, Dan& Chu, Yi Fang…[et al.]. Absorption and Elimination of Oat Avenanthramides in Humans after Acute Consumption of Oat Cookies. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1193985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193985