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Long Noncoding RNAs and RNA-Binding Proteins in Oxidative Stress, Cellular Senescence, and Age-Related Diseases
Joint Authors
Kim, Chongtae
Kang, Donghee
Lee, Eun Kyung
Lee, Jae-Seon
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-25
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Cellular senescence is a complex biological process that leads to irreversible cell-cycle arrest.
Various extrinsic and intrinsic insults are associated with the onset of cellular senescence and frequently accompany genomic or epigenomic alterations.
Cellular senescence is believed to contribute to tumor suppression, immune response, and tissue repair as well as aging and age-related diseases.
Long noncoding RNAs (lncRNAs) are >200 nucleotides long, poorly conserved, and transcribed in a manner similar to that of mRNAs.
They are tightly regulated during various cellular and physiological processes.
Although many lncRNAs and their functional roles are still undescribed, the importance of lncRNAs in a variety of biological processes is widely recognized.
RNA-binding proteins (RBPs) have a pivotal role in posttranscriptional regulation as well as in mRNA transport, storage, turnover, and translation.
RBPs interact with mRNAs, other RBPs, and noncoding RNAs (ncRNAs) including lncRNAs, and they are involved in the regulation of a broad spectrum of cellular processes.
Like other cell fate regulators, lncRNAs and RBPs, separately or cooperatively, are implicated in initiation and maintenance of cellular senescence, aging, and age-related diseases.
Here, we review the current understanding of both lncRNAs and RBPs and their association with oxidative stress, senescence, and age-related diseases.
American Psychological Association (APA)
Kim, Chongtae& Kang, Donghee& Lee, Eun Kyung& Lee, Jae-Seon. 2017. Long Noncoding RNAs and RNA-Binding Proteins in Oxidative Stress, Cellular Senescence, and Age-Related Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1193986
Modern Language Association (MLA)
Kim, Chongtae…[et al.]. Long Noncoding RNAs and RNA-Binding Proteins in Oxidative Stress, Cellular Senescence, and Age-Related Diseases. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-21.
https://search.emarefa.net/detail/BIM-1193986
American Medical Association (AMA)
Kim, Chongtae& Kang, Donghee& Lee, Eun Kyung& Lee, Jae-Seon. Long Noncoding RNAs and RNA-Binding Proteins in Oxidative Stress, Cellular Senescence, and Age-Related Diseases. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1193986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193986