The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats

Joint Authors

Neves, Kelly Rose
Costa, Roberta Oliveira da
Gadelha-Filho, Carlos Vinicius Jataí
Costa, Ayane Edwiges Moura da
Feitosa, Mariana Lima
Lucena, Jalles Dantas de
Aquino, Pedro Everson Alexandre de
Lima, Francisco Arnaldo Viana
Viana, Glauce Socorro de Barros
de Araújo, Dayane Pessoa

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-06-21

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Biology

Abstract EN

Parkinson’s disease (PD), a progressive neurological pathology, presents motor and nonmotor impairments.

The objectives were to support data on exercise benefits to PD.

Male Wistar rats were distributed into sham-operated (SO) and 6-OHDA-lesioned, both groups without and with exercise.

The animals were subjected to treadmill exercises (14 days), 24 h after the stereotaxic surgery and striatal 6-OHDA injection.

Those from no-exercise groups stayed on the treadmill for the same period and, afterwards, were subjected to behavioral tests and euthanized for neurochemical and immunohistochemical assays.

The data, analyzed by ANOVA and Tukey post hoc test, were considered significant for p<0.05.

The results showed behavioral change improvements in the 6-OHDA group, after the treadmill exercise, evaluated by apomorphine rotational behavior, open field, and rota rod tests.

The exercise reduced striatal dopaminergic neuronal loss and decreased the oxidative stress.

In addition, significant increases in BDNF contents and in immunoreactive cells to TH and DAT were also observed, in striata of the 6-OHDA group with exercise, relatively to those with no exercise.

We conclude that exercise improves behavior and dopaminergic neurotransmission in 6-OHDA-lesioned animals.

The increased oxidative stress and decreased BDNF contents were also reversed, emphasizing the importance of exercise for the PD management.

American Psychological Association (APA)

Costa, Roberta Oliveira da& Gadelha-Filho, Carlos Vinicius Jataí& Costa, Ayane Edwiges Moura da& Feitosa, Mariana Lima& de Araújo, Dayane Pessoa& Lucena, Jalles Dantas de…[et al.]. 2017. The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193992

Modern Language Association (MLA)

Costa, Roberta Oliveira da…[et al.]. The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1193992

American Medical Association (AMA)

Costa, Roberta Oliveira da& Gadelha-Filho, Carlos Vinicius Jataí& Costa, Ayane Edwiges Moura da& Feitosa, Mariana Lima& de Araújo, Dayane Pessoa& Lucena, Jalles Dantas de…[et al.]. The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193992

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1193992