The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats
Joint Authors
Neves, Kelly Rose
Costa, Roberta Oliveira da
Gadelha-Filho, Carlos Vinicius Jataí
Costa, Ayane Edwiges Moura da
Feitosa, Mariana Lima
Lucena, Jalles Dantas de
Aquino, Pedro Everson Alexandre de
Lima, Francisco Arnaldo Viana
Viana, Glauce Socorro de Barros
de Araújo, Dayane Pessoa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Parkinson’s disease (PD), a progressive neurological pathology, presents motor and nonmotor impairments.
The objectives were to support data on exercise benefits to PD.
Male Wistar rats were distributed into sham-operated (SO) and 6-OHDA-lesioned, both groups without and with exercise.
The animals were subjected to treadmill exercises (14 days), 24 h after the stereotaxic surgery and striatal 6-OHDA injection.
Those from no-exercise groups stayed on the treadmill for the same period and, afterwards, were subjected to behavioral tests and euthanized for neurochemical and immunohistochemical assays.
The data, analyzed by ANOVA and Tukey post hoc test, were considered significant for p<0.05.
The results showed behavioral change improvements in the 6-OHDA group, after the treadmill exercise, evaluated by apomorphine rotational behavior, open field, and rota rod tests.
The exercise reduced striatal dopaminergic neuronal loss and decreased the oxidative stress.
In addition, significant increases in BDNF contents and in immunoreactive cells to TH and DAT were also observed, in striata of the 6-OHDA group with exercise, relatively to those with no exercise.
We conclude that exercise improves behavior and dopaminergic neurotransmission in 6-OHDA-lesioned animals.
The increased oxidative stress and decreased BDNF contents were also reversed, emphasizing the importance of exercise for the PD management.
American Psychological Association (APA)
Costa, Roberta Oliveira da& Gadelha-Filho, Carlos Vinicius Jataí& Costa, Ayane Edwiges Moura da& Feitosa, Mariana Lima& de Araújo, Dayane Pessoa& Lucena, Jalles Dantas de…[et al.]. 2017. The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193992
Modern Language Association (MLA)
Costa, Roberta Oliveira da…[et al.]. The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1193992
American Medical Association (AMA)
Costa, Roberta Oliveira da& Gadelha-Filho, Carlos Vinicius Jataí& Costa, Ayane Edwiges Moura da& Feitosa, Mariana Lima& de Araújo, Dayane Pessoa& Lucena, Jalles Dantas de…[et al.]. The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193992