A Preclinical Systematic Review of Ginsenoside-Rg1 in Experimental Parkinson’s Disease
Joint Authors
Song, Liang
Xu, Meng-Bei
Zhou, Xiao-Li
Zhang, Dao-pei
Zhang, Shu-ling
Zheng, Guo-qing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
To date, no drug has been proven to be neuroprotective or disease-modifying for Parkinson’s disease (PD) in clinical trials.
Here, we aimed to assess preclinical evidence of Ginsenosides-Rg1 (G-Rg1), a potential neuroprotectant, for experimental PD and its possible mechanisms.
Eligible studies were identified by searching six electronic databases from their inception to August 2016.
Twenty-five eligible studies involving 516 animals were identified.
The quality score of these studies ranged from 3 to 7.
Compared with the control group, two out of the 12 studies of MPTP-induced PD showed significant effects of G-Rg1 for improving the rotarod test (P<0.01), two studies for improving the swim-score values (P<0.01), six studies for improving the level of TH protein expression (P<0.01), and two studies for increasing the expression of TH mRNA in the substantia nigra of mice (P<0.01).
The studies reported that G-Rg1 exerted potential neuroprotective effects on PD model through different mechanisms as antineuroinflammatory activities (n=10), antioxidant stress (n=3), and antiapoptosis (n=11).
In conclusion, G-Rg1 exerted potential neuroprotective functions against PD largely by antineuroinflammatory, antioxidative, and antiapoptotic effects.
G-Rg1 as a promising neuroprotectant for PD needs further confirmation by clinical trials.
American Psychological Association (APA)
Song, Liang& Xu, Meng-Bei& Zhou, Xiao-Li& Zhang, Dao-pei& Zhang, Shu-ling& Zheng, Guo-qing. 2017. A Preclinical Systematic Review of Ginsenoside-Rg1 in Experimental Parkinson’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1193998
Modern Language Association (MLA)
Song, Liang…[et al.]. A Preclinical Systematic Review of Ginsenoside-Rg1 in Experimental Parkinson’s Disease. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1193998
American Medical Association (AMA)
Song, Liang& Xu, Meng-Bei& Zhou, Xiao-Li& Zhang, Dao-pei& Zhang, Shu-ling& Zheng, Guo-qing. A Preclinical Systematic Review of Ginsenoside-Rg1 in Experimental Parkinson’s Disease. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1193998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193998