Methane Suppresses Microglial Activation Related to Oxidative, Inflammatory, and Apoptotic Injury during Spinal Cord Injury in Rats
Joint Authors
Yu, Jiangming
Xi, Yanhai
Ye, Xiaojian
Xie, Ning
Wang, WeiHeng
Huang, Xiaodong
Li, Jian
Sun, Aijun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
We investigated the hypothesis that methane-rich saline (MS) can be used to repair spinal cord injury (SCI) in a rat model through suppressing microglial activation related to oxidative, inflammatory, and apoptotic injury.
Methods.
MS was injected intraperitoneally in rats after SCI.
Hematoxylin-eosin (HE) staining, oxidative stress, inflammatory parameters, and cell apoptosis were detected 72 h after SCI to determine the optimal dose.
Then, we investigated the protective mechanisms and the long-term effects of MS on SCI.
HE and microglial activation were observed.
Neurological function was evaluated by the Basso, Beattie, and Bresnahan (BBB) scale.
Results.
MS can significantly decrease infarct area and inhibit oxidative stress, inflammation, and cell apoptosis 72 h following SCI.
The MS protective effect at a dose of 20 ml/kg was better.
Moreover, MS can significantly suppress microglial activation related to oxidative and inflammatory injury after SCI and improve hind limb neurological function.
Conclusion.
MS could repair SCI and reduce the release of oxidative stress, inflammatory cytokines, and cell apoptosis produced by activated microglia.
MS provides a novel and promising strategy for the treatment of SCI.
American Psychological Association (APA)
Wang, WeiHeng& Huang, Xiaodong& Li, Jian& Sun, Aijun& Yu, Jiangming& Xie, Ning…[et al.]. 2017. Methane Suppresses Microglial Activation Related to Oxidative, Inflammatory, and Apoptotic Injury during Spinal Cord Injury in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1194029
Modern Language Association (MLA)
Wang, WeiHeng…[et al.]. Methane Suppresses Microglial Activation Related to Oxidative, Inflammatory, and Apoptotic Injury during Spinal Cord Injury in Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1194029
American Medical Association (AMA)
Wang, WeiHeng& Huang, Xiaodong& Li, Jian& Sun, Aijun& Yu, Jiangming& Xie, Ning…[et al.]. Methane Suppresses Microglial Activation Related to Oxidative, Inflammatory, and Apoptotic Injury during Spinal Cord Injury in Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1194029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194029