Nrf2, a Potential Therapeutic Target against Oxidative Stress in Corneal Diseases
Joint Authors
Hao, Jilong
Liu, Xiu-Fen
Zhou, Dan-Dan
Xie, Tian
Malik, Tayyab Hamid
Lu, Cheng-Bo
Li, Hai-Jun
Wang, Fan
Shu, Chang
Liu, Cong
Lu, Cheng-Wei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Corneal diseases are one of the major causes of blindness worldwide.
Conservative medical agents, which may prevent sight-threatening corneal disease progression, are urgently desired.
Numerous evidences have revealed the involvement of oxidative stress in various corneal diseases, such as corneal wound healing and Fuchs endothelial corneal dystrophy (FECD).
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like erythroid-cell-derived protein with CNC homology- (ECH-) associated protein 1 (Keap1)/antioxidant response element (ARE) signaling is well known as one of the main antioxidative defense systems.
To the best of our knowledge, this is the first review to elucidate the different expression profiles of Nrf2 signaling as well as the underlying mechanisms in corneal diseases, implicating that Nrf2 may serve as a potentially promising therapeutic target for corneal diseases.
American Psychological Association (APA)
Liu, Xiu-Fen& Zhou, Dan-Dan& Xie, Tian& Malik, Tayyab Hamid& Lu, Cheng-Bo& Li, Hai-Jun…[et al.]. 2017. Nrf2, a Potential Therapeutic Target against Oxidative Stress in Corneal Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1194039
Modern Language Association (MLA)
Liu, Xiu-Fen…[et al.]. Nrf2, a Potential Therapeutic Target against Oxidative Stress in Corneal Diseases. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1194039
American Medical Association (AMA)
Liu, Xiu-Fen& Zhou, Dan-Dan& Xie, Tian& Malik, Tayyab Hamid& Lu, Cheng-Bo& Li, Hai-Jun…[et al.]. Nrf2, a Potential Therapeutic Target against Oxidative Stress in Corneal Diseases. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1194039
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194039