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The Roles of ROS in Cancer Heterogeneity and Therapy
Joint Authors
De Sá Júnior, Paulo Luiz
Araldi, R. P.
Câmara, Diana Aparecida Dias
Porcacchia, Allan Saj
Fonseca, Pâmela Maria Moreira
Jorge, Salomão Doria
Ferreira, Adilson Kleber
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cancer comprises a group of heterogeneous diseases encompassing high rates of morbidity and mortality.
Heterogeneity, which is a hallmark of cancer, is one of the main factors related to resistance to chemotherapeutic agents leading to poor prognosis.
Heterogeneity is profoundly affected by increasing levels of ROS.
Under low concentrations, ROS may function as signaling molecules favoring tumorigenesis and heterogeneity, while under high ROS concentrations, these species may work as cancer modulators due to their deleterious, genotoxic or even proapoptotic effect on cancer cells.
This double-edged sword effect represented by ROS relies on their ability to cause genetic and epigenetic modifications in DNA structure.
Antitumor therapeutic approaches may use molecules that prevent the ROS formation precluding carcinogenesis or use chemical agents that promote a sudden increase of ROS causing considerable oxidative stress inside tumor mass.
Therefore, herein, we review what ROS are and how they are produced in normal and in cancer cells while providing an argumentative discussion about their role in cancer pathophysiology.
We also describe the various sources of ROS in cancer and their role in tumor heterogeneity.
Further, we also discuss some therapeutic strategies from the current landscape of cancer heterogeneity, ROS modulation, or ROS production.
American Psychological Association (APA)
De Sá Júnior, Paulo Luiz& Câmara, Diana Aparecida Dias& Porcacchia, Allan Saj& Fonseca, Pâmela Maria Moreira& Jorge, Salomão Doria& Araldi, R. P.…[et al.]. 2017. The Roles of ROS in Cancer Heterogeneity and Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194071
Modern Language Association (MLA)
De Sá Júnior, Paulo Luiz…[et al.]. The Roles of ROS in Cancer Heterogeneity and Therapy. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194071
American Medical Association (AMA)
De Sá Júnior, Paulo Luiz& Câmara, Diana Aparecida Dias& Porcacchia, Allan Saj& Fonseca, Pâmela Maria Moreira& Jorge, Salomão Doria& Araldi, R. P.…[et al.]. The Roles of ROS in Cancer Heterogeneity and Therapy. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194071