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Effect of Content of Sulfate Groups in Seaweed Polysaccharides on Antioxidant Activity and Repair Effect of Subcellular Organelles in Injured HK-2 Cells
Joint Authors
Ouyang, Jian-Ming
Sun, Xin-Yuan
Ma, Xiao-Tao
Yu, Kai
Gui, Qin
Gui, Bao-Song
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This study aims to investigate the repair effect of subcellular structure injuries of the HK-2 cells of four degraded seaweed polysaccharides (DSPs), namely, the degraded Porphyra yezoensis, Gracilaria lemaneiformis, Sargassum fusiform, and Undaria pinnatifida polysaccharides.
The four DSPs have similar molecular weight, but with different content of sulfate groups (i.e., 17.9%, 13.3%, 8.2%, and 5.5%, resp.).
The damaged model was established using 2.8 mmol/L oxalate to injure HK-2 cells, and 60 μg/mL of various DSPs was used to repair the damaged cells.
With the increase of sulfate group content in DSPs, the scavenging activity of radicals and their reducing power were all improved.
Four kinds of DSPs have repair effect on the subcellular organelles of damaged HK-2 cells.
After being repaired by DSPs, the release amount of lactate dehydrogenase was decreased, the integrity of cell membrane and lysosome increased, the Δψm increased, the cell of G1 phase arrest was inhibited, the proportion of S phase increased, and cell apoptotic and necrosis rates were significantly reduced.
The greater the content of sulfate group is, the stronger is the repair ability of the polysaccharide.
These DSPs, particularly the polysaccharide with higher sulfate group content, may be a potential drug for the prevention and cure of kidney stones.
American Psychological Association (APA)
Ma, Xiao-Tao& Sun, Xin-Yuan& Yu, Kai& Gui, Bao-Song& Gui, Qin& Ouyang, Jian-Ming. 2017. Effect of Content of Sulfate Groups in Seaweed Polysaccharides on Antioxidant Activity and Repair Effect of Subcellular Organelles in Injured HK-2 Cells. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194086
Modern Language Association (MLA)
Ma, Xiao-Tao…[et al.]. Effect of Content of Sulfate Groups in Seaweed Polysaccharides on Antioxidant Activity and Repair Effect of Subcellular Organelles in Injured HK-2 Cells. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1194086
American Medical Association (AMA)
Ma, Xiao-Tao& Sun, Xin-Yuan& Yu, Kai& Gui, Bao-Song& Gui, Qin& Ouyang, Jian-Ming. Effect of Content of Sulfate Groups in Seaweed Polysaccharides on Antioxidant Activity and Repair Effect of Subcellular Organelles in Injured HK-2 Cells. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194086