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Effect of Multicomponent Training on Blood Pressure, Nitric Oxide, Redox Status, and Physical Fitness in Older Adult Women: Influence of Endothelial Nitric Oxide Synthase (NOS3) Haplotypes
Joint Authors
Tanus-Santos, José Eduardo
Mourão Jacomini, André
Cezar Pinheiro, Lucas
Alexandre Trapé, Atila
Lizzi, Elisangela Aparecida da Silva
Gonçalves, Thiago Correa Porto
Rodrigues, Jhennyfer Aline Lima
Tavares, Simone Sakagute
Lacchini, Riccardo
Ferreira, Graziele Cristina
Ovídio, Paula Payão
Jordão, Alceu Afonso
Zago, Anderson Saranz
Bueno, Carlos Roberto
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The purpose of this study was to verify the influence of the genotype or haplotype (interaction) of the NOS3 polymorphisms [-786T>C, 894G>T (Glu298Asp), and intron 4b/a] on the response to multicomponent training (various capacities and motor skills) on blood pressure (BP), nitrite concentration, redox status, and physical fitness in older adult women.
The sample consisted of 52 participants, who underwent body mass index and BP assessments.
Physical fitness was evaluated by six-minute walk, elbow flexion, and sit and stand up tests.
Plasma/blood samples were used to evaluate redox status, nitrite concentration, and genotyping.
Associations were observed between isolated polymorphisms and the response of decreased systolic and diastolic BP and increased nitrite concentration and antioxidant activity.
In the haplotype analysis, the group composed of ancestral alleles (H1) was the only one to present improvement in all variables studied (decrease in systolic and diastolic BP, improvement in nitrite concentration, redox status, and physical fitness), while the group composed of variant alleles (H8) only demonstrated improvement in some variables of redox status and physical fitness.
These findings suggest that NOS3 polymorphisms and physical training are important interacting variables to consider in evaluating redox status, nitric oxide availability and production, and BP control.
American Psychological Association (APA)
Alexandre Trapé, Atila& Lizzi, Elisangela Aparecida da Silva& Gonçalves, Thiago Correa Porto& Rodrigues, Jhennyfer Aline Lima& Tavares, Simone Sakagute& Lacchini, Riccardo…[et al.]. 2017. Effect of Multicomponent Training on Blood Pressure, Nitric Oxide, Redox Status, and Physical Fitness in Older Adult Women: Influence of Endothelial Nitric Oxide Synthase (NOS3) Haplotypes. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194087
Modern Language Association (MLA)
Alexandre Trapé, Atila…[et al.]. Effect of Multicomponent Training on Blood Pressure, Nitric Oxide, Redox Status, and Physical Fitness in Older Adult Women: Influence of Endothelial Nitric Oxide Synthase (NOS3) Haplotypes. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194087
American Medical Association (AMA)
Alexandre Trapé, Atila& Lizzi, Elisangela Aparecida da Silva& Gonçalves, Thiago Correa Porto& Rodrigues, Jhennyfer Aline Lima& Tavares, Simone Sakagute& Lacchini, Riccardo…[et al.]. Effect of Multicomponent Training on Blood Pressure, Nitric Oxide, Redox Status, and Physical Fitness in Older Adult Women: Influence of Endothelial Nitric Oxide Synthase (NOS3) Haplotypes. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194087