![](/images/graphics-bg.png)
Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches
Joint Authors
Leone, Alessandra
Roca, Maria Serena
Ciardiello, Chiara
Costantini, Susan
Budillon, Alfredo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-09
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The role of altered redox status and high reactive oxygen species (ROS) is still controversial in cancer development and progression.
Intracellular levels of ROS are elevated in cancer cells suggesting a role in cancer initiation and progression; on the contrary, ROS elevated levels may induce programmed cell death and have been associated with cancer suppression.
Thus, it is crucial to consider the double-face of ROS, for novel therapeutic strategies targeting redox regulatory mechanisms.
In this review, in order to derive cancer-type specific oxidative stress genes’ profile and their potential prognostic role, we integrated a publicly available oxidative stress gene signature with patient survival data from the Cancer Genome Atlas database.
Overall, we found several genes statistically significant associated with poor prognosis in the examined six tumor types.
Among them, FoxM1 and thioredoxin reductase1 expression showed the same pattern in four out of six cancers, suggesting their specific critical role in cancer-related oxidative stress adaptation.
Our analysis also unveiled an enriched cellular network, highlighting specific pathways, in which many genes are strictly correlated.
Finally, we discussed novel findings on the correlation between oxidative stress and cancer stem cells in order to define those pathways to be prioritized in drug development.
American Psychological Association (APA)
Leone, Alessandra& Roca, Maria Serena& Ciardiello, Chiara& Costantini, Susan& Budillon, Alfredo. 2017. Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1194090
Modern Language Association (MLA)
Leone, Alessandra…[et al.]. Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1194090
American Medical Association (AMA)
Leone, Alessandra& Roca, Maria Serena& Ciardiello, Chiara& Costantini, Susan& Budillon, Alfredo. Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1194090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194090