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Stress-Activated Degradation of Sphingolipids Regulates Mitochondrial Function and Cell Death in Yeast
Joint Authors
Manzanares-Estreder, Sara
Pascual-Ahuir, Amparo
Proft, Markus
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Sphingolipids are regulators of mitochondria-mediated cell death in higher eukaryotes.
Here, we investigate how changes in sphingolipid metabolism and downstream intermediates of sphingosine impinge on mitochondrial function.
We found in yeast that within the sphingolipid degradation pathway, the production via Dpl1p and degradation via Hfd1p of hexadecenal are critical for mitochondrial function and cell death.
Genetic interventions, which favor hexadecenal accumulation, diminish oxygen consumption rates and increase reactive oxygen species production and mitochondrial fragmentation and vice versa.
The location of the hexadecenal-degrading enzyme Hfd1p in punctuate structures all along the mitochondrial network depends on a functional ERMES (endoplasmic reticulum-mitochondria encounter structure) complex, indicating that modulation of hexadecenal levels at specific ER-mitochondria contact sites might be an important trigger of cell death.
This is further supported by the finding that externally added hexadecenal or the absence of Hfd1p enhances cell death caused by ectopic expression of the human Bax protein.
Finally, the induction of the sphingolipid degradation pathway upon stress is controlled by the Hog1p MAP kinase.
Therefore, the stress-regulated modulation of sphingolipid degradation might be a conserved way to induce cell death in eukaryotic organisms.
American Psychological Association (APA)
Manzanares-Estreder, Sara& Pascual-Ahuir, Amparo& Proft, Markus. 2017. Stress-Activated Degradation of Sphingolipids Regulates Mitochondrial Function and Cell Death in Yeast. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1194113
Modern Language Association (MLA)
Manzanares-Estreder, Sara…[et al.]. Stress-Activated Degradation of Sphingolipids Regulates Mitochondrial Function and Cell Death in Yeast. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1194113
American Medical Association (AMA)
Manzanares-Estreder, Sara& Pascual-Ahuir, Amparo& Proft, Markus. Stress-Activated Degradation of Sphingolipids Regulates Mitochondrial Function and Cell Death in Yeast. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1194113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194113