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The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System
Joint Authors
De Falco, Elena
Chimenti, Isotta
Angelini, Francesco
Peruzzi, Mariangela
Marullo, Antonino G. M.
Sciarretta, Sebastiano
Frati, G.
Bordin, Antonella
Schirone, Leonardo
Palmerio, Silvia
Pagano, Francesca
Milan, Marika
Valenti, Valentina
Murdoch, Colin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-21
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Oxidative states exert a significant influence on a wide range of biological and molecular processes and functions.
When their balance is shifted towards enhanced amounts of free radicals, pathological phenomena can occur, as the generation of reactive oxygen species (ROS) in tissue microenvironment or in the systemic circulation can be detrimental.
Epidemic chronic diseases of western societies, such as cardiovascular disease, obesity, and diabetes correlate with the imbalance of redox homeostasis.
Current advances in our understanding of epigenetics have revealed a parallel scenario showing the influence of oxidative stress as a major regulator of epigenetic gene regulation via modification of DNA methylation, histones, and microRNAs.
This has provided both the biological link and a potential molecular explanation between oxidative stress and cardiovascular/metabolic phenomena.
Accordingly, in this review, we will provide current insights on the physiological and pathological impact of changes in oxidative states on cardiovascular disorders, by specifically focusing on the influence of epigenetic regulation.
A special emphasis will highlight the effect on epigenetic regulation of human’s current life habits, external and environmental factors, including food intake, tobacco, air pollution, and antioxidant-based approaches.
Additionally, the strategy to quantify oxidative states in humans in order to determine which biological marker could best match a subject’s profile will be discussed.
American Psychological Association (APA)
Angelini, Francesco& Pagano, Francesca& Bordin, Antonella& Milan, Marika& Chimenti, Isotta& Peruzzi, Mariangela…[et al.]. 2017. The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1194132
Modern Language Association (MLA)
Angelini, Francesco…[et al.]. The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1194132
American Medical Association (AMA)
Angelini, Francesco& Pagano, Francesca& Bordin, Antonella& Milan, Marika& Chimenti, Isotta& Peruzzi, Mariangela…[et al.]. The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1194132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194132